Universität zu Köln

Balavarca, Y., Pearce, K., Norden, J., Collin, M., Jackson, G., Holler, E., Dressel, R., Kolb, H-J, Greinix, H., Socie, G., Toubert, A., Rocha, V., Gluckman, E., Hromadnikova, I., Sedlacek, P., Wolff, D., Holtick, U., Dickinson, A. and Bickeboeller, H. (2015). Predicting survival using clinical risk scores and non-HLA immunogenetics. Bone Marrow Transplant., 50 (11). S. 1445 - 1453. LONDON: NATURE PUBLISHING GROUP. ISSN 1476-5365

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Abstract

Previous studies of non-histocompatibility leukocyte antigen (HLA) gene single-nucleotide polymorphisms (SNPs) on subgroups of patients undergoing allogeneic haematopoietic stem cell transplantation (HSCT) revealed an association with transplant outcome. This study further evaluated the association of non-HLA polymorphisms with overall survival in a cohort of 762 HSCT patients using data on 26 polymorphisms in 16 non-HLA genes. When viewed in addition to an already established clinical risk score (EBMT-score), three polymorphisms: rs8177374 in the gene for MyD88-adapter-like (MAL; P = 0.026), rs9340799 in the oestrogen receptor gene (ESR; P = 0.003) and rs1800795 in interleukin-6 (IL-6; P = 0.007) were found to be associated with reduced overall survival, whereas the haplo-genotype (ACC/ACC) in IL-10 was protective (P = 0.02). The addition of these non-HLA polymorphisms in a Cox regression model alongside the EBMT-score improved discrimination between risk groups and increased the level of prediction compared with the EBMT-score alone (gain in prediction capability for EBMT-genetic-score 10.8%). Results also demonstrated how changes in clinical practice through time have altered the effects of non-HLA analysis. The study illustrates the significance of non-HLA genotyping prior to HSCT and the importance of further investigation into non-HLA gene polymorphisms in risk prediction.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Balavarca, Y. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pearce, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Norden, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Collin, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jackson, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Holler, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dressel, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kolb, H-J UNSPECIFIED UNSPECIFIED UNSPECIFIED Greinix, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Socie, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Toubert, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rocha, V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gluckman, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hromadnikova, I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sedlacek, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wolff, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Holtick, U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dickinson, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bickeboeller, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-387482
DOI:	10.1038/bmt.2015.173
Journal or Publication Title:	Bone Marrow Transplant.
Volume:	50
Number:	11
Page Range:	S. 1445 - 1453
Date:	2015
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	1476-5365
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language VERSUS-HOST-DISEASE; STEM-CELL TRANSPLANTATION; GENE POLYMORPHISM; PROMOTER POLYMORPHISM; IN-VITRO; MESSENGER-RNA; RECEPTOR; IDENTIFICATION; ASSOCIATION; EXPRESSION Multiple languages Biophysics; Oncology; Hematology; Immunology; Transplantation Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/38748