Heindl, L. M., Koch, K. R., Schlaak, M., Mauch, C. and Cursiefen, C. (2015). Adjuvant therapy and interdisciplinary follow-up care of conjunctival melanoma. Ophthalmologe, 112 (11). S. 907 - 912. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1433-0423
Full text not available from this repository.Abstract
Despite microscopically controlled tumor excision, malignant melanomas of the conjunctiva have a propensity for local recurrence, lymphatic spread and distant metastases. This review outlines the options of adjuvant therapy as well as the structure of interdisciplinary follow-up care for patients with conjunctival melanoma. The study provides a PubMed literature review and own clinical results. In conjunctival melanoma complete tumor excision using a minimal touch technique should always be combined with adjuvant therapy, such as cryotherapy, radiotherapy, topical chemotherapy and/or immunotherapy. For locally circumscribed lesions of the bulbar conjunctiva adjuvant brachytherapy can be supplemented and for non-bulbar, extensive, diffuse or multilocular tumor growth, complementary adjuvant topical mitomycin C therapy or proton radiotherapy can be used. Novel adjuvant approaches include topical interferon alpha-2b immunotherapy, topical vascular endothelial growth factor (VEGF) inhibitors or in cases of BRAF mutations personalized therapy using selective BRAF inhibitors or in combination with mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK), MAPK/ERK (MEK) inhibitors. All patients should be integrated into an interdisciplinary follow-up care program including quarter yearly checkups in the first 5 years and psycho-oncological healthcare. Following microscopically controlled tumor excision, adjuvant treatment using cryotherapy, radiotherapy, topical chemotherapy and/or immunotherapy as well as interdisciplinary follow-up care are mandatory for the modern management of patients with conjunctival melanoma.
Item Type: | Journal Article | ||||||||||||||||||||||||
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URN: | urn:nbn:de:hbz:38-387950 | ||||||||||||||||||||||||
DOI: | 10.1007/s00347-015-0141-4 | ||||||||||||||||||||||||
Journal or Publication Title: | Ophthalmologe | ||||||||||||||||||||||||
Volume: | 112 | ||||||||||||||||||||||||
Number: | 11 | ||||||||||||||||||||||||
Page Range: | S. 907 - 912 | ||||||||||||||||||||||||
Date: | 2015 | ||||||||||||||||||||||||
Publisher: | SPRINGER HEIDELBERG | ||||||||||||||||||||||||
Place of Publication: | HEIDELBERG | ||||||||||||||||||||||||
ISSN: | 1433-0423 | ||||||||||||||||||||||||
Language: | German | ||||||||||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||||||||||
Subjects: | no entry | ||||||||||||||||||||||||
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URI: | http://kups.ub.uni-koeln.de/id/eprint/38795 |
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