Universität zu Köln

Toteberg-Harms, M., Rosentreter, A., Lappas, A., Funk, J. and Dietlein, T. S. (2015). Current aspects on the management of normal tension glaucoma. Ophthalmologe, 112 (11). S. 943 - 957. NEW YORK: SPRINGER. ISSN 1433-0423

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Abstract

In a considerable proportion of glaucoma patients (25-50 %) the intraocular pressure (IOP) is not elevated higher than 22 mmHg at first diagnosis and during subsequent follow-up controls. Although the IOP level remains in the low range < 22 mmHg, progression of glaucoma can still occur. A multitude of different factors are assumed to be involved in glaucoma progression, such as very low nocturnal diastolic blood pressure values, a low mean ocular perfusion pressure, extensive fluctuations in perfusion (e.g. in cases of vascular dysregulation), an increased vulnerability of the optic nerve support structures, an increased translaminar pressure gradient and various underlying systemic diseases. The most important evidence-based aspect of treatment in normal tension glaucoma is pharmaceutical or surgical reduction of the IOP by 30 % or more in comparison to the initial pressure level. Vascular and neuroprotective concepts of treatment for normal tension glaucoma have been strongly advocated and the object of experimental and clinical studies. As yet a clear clinical benefit has not been proven by large prospective randomized studies.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Toteberg-Harms, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rosentreter, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lappas, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Funk, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dietlein, T. S. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-387983
DOI:	10.1007/s00347-015-0140-5
Journal or Publication Title:	Ophthalmologe
Volume:	112
Number:	11
Page Range:	S. 943 - 957
Date:	2015
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1433-0423
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SELECTIVE LASER TRABECULOPLASTY; OPEN-ANGLE GLAUCOMA; OCULAR PERFUSION-PRESSURE; GINKGO-BILOBA EXTRACT; VISUAL-FIELD DAMAGE; OPTIC-NERVE HEAD; INTRAOCULAR-PRESSURE; FOLLOW-UP; RISK-FACTORS; ISCHEMIC DISORDERS Multiple languages Ophthalmology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/38798