Universität zu Köln

Kleinert, Robert, Prenzel, Klaus, Stoecklein, Nikolas, Alakus, Hakan, Bollschweiler, Elfriede, Hoelscher, Arnulf and Warnecke-Eberz, Ute (2015). Gene Expression of Col11A1 Is a Marker Not only for Pancreas Carcinoma But also for Adenocarcinoma of the Papilla of Vater, Discriminating Between Carcinoma and Chronic Pancreatitis. Anticancer Res., 35 (11). S. 6153 - 6159. ATHENS: INT INST ANTICANCER RESEARCH. ISSN 1791-7530

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Abstract

Aim: For tumors of the periampullary region clinical differentiation between primary and tumor-associated pancreatitis might be difficult. Early diagnosis of these malignancies is essential, as they present with early invasion of surrounding tissue thus limiting therapeutic options. Using molecular markers, the preoperative diagnosis (EUS-guided needle biopsy, brush biopsy pancreatic duct) could be optimized and surgical therapy potentially adapted. Alpha1 (XI) collagen Col11A1 is essential for the extracellular matrix and normal skeletal development and has been associated with carcinogenesis. Materials and Methods: Forty-three patients with adenocarcinoma of the pancreas, 11 with adenocarcinoma of the papilla of Vater and 23 patients with chronic pancreatitis were included in the study. For all patients mRNA expression of Col11A1 was quantified by TaqMan RT-PCR in tumor or pancreatitis specimen, as well as in the corresponding normal uninvolved tissue and correlated with diagnosis of cancer and chronic pancreatitis. Results: Col11A1 mRNA expression was 5.25-fold higher in adenocarcinoma of the pancreas (p= 0.006) and 8.25-fold in the papilla of Vater (p= 0.002) compared to that of chronic pancreatitis specimen. Conclusion: Differential mRNA expression of Col11A1 may be applied to preoperatively differentiate between tumors of the periampullary region and chronic pancreatitis and this may potentially have a positive effect on patient survival.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kleinert, Robert UNSPECIFIED UNSPECIFIED UNSPECIFIED Prenzel, Klaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Stoecklein, Nikolas UNSPECIFIED UNSPECIFIED UNSPECIFIED Alakus, Hakan UNSPECIFIED UNSPECIFIED UNSPECIFIED Bollschweiler, Elfriede UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoelscher, Arnulf UNSPECIFIED UNSPECIFIED UNSPECIFIED Warnecke-Eberz, Ute UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-388179
Journal or Publication Title:	Anticancer Res.
Volume:	35
Number:	11
Page Range:	S. 6153 - 6159
Date:	2015
Publisher:	INT INST ANTICANCER RESEARCH
Place of Publication:	ATHENS
ISSN:	1791-7530
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NEOADJUVANT RADIOCHEMOTHERAPY; MESSENGER-RNA; CANCER; DIAGNOSIS; PREDICTION; SIGNATURE; SURVIVAL; SURGERY Multiple languages Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/38817