Saunders, Derek J., Muether, Philipp S. and Fauser, Sascha (2015). A model of the ocular pharmacokinetics involved in the therapy of neovascular age-related macular degeneration with ranibizumab. Br. J. Ophthalmol., 99 (11). S. 1554 - 1560. LONDON: BMJ PUBLISHING GROUP. ISSN 1468-2079
Full text not available from this repository.Abstract
Background To develop a model of the pharmacokinetics of vascular endothelial growth factor (VEGF-A) determined in samples of aqueous humour from patients with neovascular age-related macular degeneration (AMD) treated with ranibizumab (Lucentis). Methods Post hoc analysis of data from 31 eyes of 31 patients with AMD treated with ranibizumab gathered in a non-randomised, prospective clinical study. VEGF-A concentrations were measured in 440 aqueous humour samples by Luminex multiplex bead analysis (Luminex, Austin, Texas, USA). Results The kinetics of recovery of VEGF-A from suppression by ranibizumab were well described by a simple model: VEGF-A is produced at a constant individual rate; VEGF-A and ranibizumab disperse rapidly within the vitreous chamber and bind with a known affinity; both are eliminated at identical rates from the vitreous chamber in a constant but individual flow into the anterior chamber, and are finally cleared by draining into the peripheral circulation. Average rates of VEGF-A production were predicted to be 5.8 fmol/day (range: 2.7-10.1 fmol), and elimination half-times predicted to be 3.5 days (range: 2.3-5.5 days). The duration of complete VEGF-A suppression in the aqueous humour averaged 41 days (range: 28-67 days). Conclusions The ocular pharmacokinetics of VEGF-A and ranibizumab have been linked for the first time in a simple and plausible model which suggests that it might be possible to anticipate individual VEGF-A suppression times.
Item Type: | Journal Article | ||||||||||||||||
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URN: | urn:nbn:de:hbz:38-388382 | ||||||||||||||||
DOI: | 10.1136/bjophthalmol-2015-306771 | ||||||||||||||||
Journal or Publication Title: | Br. J. Ophthalmol. | ||||||||||||||||
Volume: | 99 | ||||||||||||||||
Number: | 11 | ||||||||||||||||
Page Range: | S. 1554 - 1560 | ||||||||||||||||
Date: | 2015 | ||||||||||||||||
Publisher: | BMJ PUBLISHING GROUP | ||||||||||||||||
Place of Publication: | LONDON | ||||||||||||||||
ISSN: | 1468-2079 | ||||||||||||||||
Language: | English | ||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||
Subjects: | no entry | ||||||||||||||||
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URI: | http://kups.ub.uni-koeln.de/id/eprint/38838 |
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