Universität zu Köln

Camilleri, Julia A., Reid, Andrew T., Mueller, Veronika I., Grefkes, Christian ORCID: 0000-0002-1656-720X, Amunts, Katrin ORCID: 0000-0001-5828-0867 and Eickhoff, Simon B. ORCID: 0000-0001-6363-2759 (2015). Multi-modal imaging of neural correlates of motor speed performance in the trail making test. Front. Neurol., 6. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1664-2295

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Abstract

The assessment of motor and executive functions following stroke or traumatic brain injury is a key aspect of impairment evaluation and used to guide further therapy. In clinical routine, such assessments are largely dominated by pen-and-paper tests. While these provide standardized, reliable, and ecologically valid measures of the individual level of functioning, rather little is yet known about their neurobiological underpinnings. Therefore, the aim of this study was to investigate brain regions and their associated networks that are related to upper extremity motor function, as quantified by the motor speed subtest of the trail making test (TMT-MS). Whole-brain voxel-based morphometry and whole-brain tract-based spatial statistics were used to investigate the association between TMT-MS performance with gray-matter volume (GMV) and white-matter integrity, respectively. While results demonstrated no relationship to local white-matter properties, we found a significant correlation between TMT-MS performance and GMV of the lower bank of the inferior frontal sulcus, a region associated with cognitive processing, as indicated by assessing its functional profile by the BrainMap database. Using this finding as a seed region, we further examined and compared networks as reflected by resting state connectivity, meta-analytic connectivity modeling, structural covariance, and probabilistic tractography. While differences between the different approaches were observed, all approaches converged on a network comprising regions that overlap with the multiple-demand network. Our data therefore indicate that performance may primarily depend on executive function, thus suggesting that motor speed in a more naturalistic setting should be more associated with executive rather than primary motor function. Moreover, results showed that while there were differences between the approaches, a convergence indicated that common networks can be revealed across highly divergent methods.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Camilleri, Julia A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Reid, Andrew T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Veronika I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Grefkes, Christian UNSPECIFIED orcid.org/0000-0002-1656-720X UNSPECIFIED Amunts, Katrin UNSPECIFIED orcid.org/0000-0001-5828-0867 UNSPECIFIED Eickhoff, Simon B. UNSPECIFIED orcid.org/0000-0001-6363-2759 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-389387
DOI:	10.3389/fneur.2015.00219
Journal or Publication Title:	Front. Neurol.
Volume:	6
Date:	2015
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	1664-2295
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language STATE FUNCTIONAL CONNECTIVITY; SUBJECT DIFFUSION DATA; HUMAN BRAIN; STRUCTURAL CONNECTIVITY; CORTICAL THICKNESS; SPATIAL STATISTICS; VOXELWISE ANALYSIS; NETWORKS; CORTEX; COVARIANCE Multiple languages Clinical Neurology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/38938