Universität zu Köln

Krakau, Michael, Gerbershagen, Kathrin, Frost, Ulrich, Hinzke, Markus, Brockmann, Michael, Schildgen, Verena, Gossmann, Axel, Limmroth, Volker, Dormann, Arno and Schildgen, Oliver ORCID: 0000-0003-4297-9627 (2015). Case Report: Human Bocavirus Associated Pneumonia as Cause of Acute Injury, Cologne, Germany. Medicine (Baltimore), 94 (42). PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1536-5964

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Abstract

Although the human bocavirus (HBoV) is known since a decade, limited information about its pathogenesis is available due to the lack of an animal model. Thus, clinical cases and studies are the major source of novel information about the course of infection and the related pathophysiology. In this context, a clinical case of an adult patient suffering from severe HBoV-pneumonia is described that was associated with loss of consciousness followed by acute rib fracture and subsequent neurological disorder. Following initial global respiratory dysfunction the clinical respiratory symptoms recovered but the neurological symptoms maintained after weaning and intensive care in the stroke unit. During the initial phase, an acute active HBoV infection was confirmed by positive polymerase chain reactions from bronchoalveolar lavage fluid and serum. The case further demonstrates that HBoV can cause severe pneumonia, induce secondary disease also in adults, and may be associated with neurological symptoms as previously assumed.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Krakau, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Gerbershagen, Kathrin UNSPECIFIED UNSPECIFIED UNSPECIFIED Frost, Ulrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Hinzke, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Brockmann, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Schildgen, Verena UNSPECIFIED UNSPECIFIED UNSPECIFIED Gossmann, Axel UNSPECIFIED UNSPECIFIED UNSPECIFIED Limmroth, Volker UNSPECIFIED UNSPECIFIED UNSPECIFIED Dormann, Arno UNSPECIFIED UNSPECIFIED UNSPECIFIED Schildgen, Oliver UNSPECIFIED orcid.org/0000-0003-4297-9627 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-390154
DOI:	10.1097/MD.0000000000001587
Journal or Publication Title:	Medicine (Baltimore)
Volume:	94
Number:	42
Date:	2015
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	1536-5964
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HOSPITALIZED CHILDREN; INFECTIONS; ENCEPHALITIS Multiple languages Medicine, General & Internal Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/39015