Universität zu Köln

Eminaga, Okyaz, Hinkelammert, Reemt, Abbas, Mahmoud, Woetzel, Fabian, Eltze, Elke, Bettendorf, Olaf, Boegemann, Martin and Semjonow, Axel (2015). Preoperative Serum Prostate-Specific Antigen Levels Vary According to the Topographical Distribution of Prostate Cancer in Prostatectomy Specimens. Urology, 86 (4). S. 798 - 805. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1527-9995

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Abstract

OBJECTIVE To evaluate whether the spatial distribution of prostate cancer (PCa) influences the concentration of prostate-specific antigen (PSA). METHODS An observational prospective study was performed in 775 consecutive men with preoperative PSA levels <= 20 ng/mL who underwent radical prostatectomy for organ-confined PCa. We evaluated prostate specimens using a cMDX-based map model of the prostate and determined the prostate volume, number of cancer foci, relative tumor volume, Gleason score, zone of origin, localization, and pathologic stage after stratification according to PSA levels categorized into 3 groups: <4 ng/mL, 4-10 ng/mL, and 10.1-20 ng/mL. The distribution of 5254 PCa foci was analyzed after stratification according to PSA levels and visualized on heat maps. A logistic regression analysis was performed to assess the odds ratios of PSA levels for the presence of PCa in 16 regions. RESULTS PCa with PSA <4 ng/mL was predominantly localized to the apical part and the peripheral zone of the prostate. PCa with a PSA level 10.1-20 ng/mL (16.4% of cases) was observed more frequently in the anterior part and the base of the prostate than PCa with a PSA level <4 or 410 ng/mL (6% and 10%, respectively). CONCLUSION Preoperative PSA levels vary according to the spatial distribution of PCa in radical prostatectomy specimens. The probability of anterior PCa is increased with higher PSA serum levels. Regions of interest harboring the PCa can be defined according to preoperative PSA and prostate volume. These findings are useful to optimize the focal therapy or to adjust the radiation fields. (C) 2015 Elsevier Inc.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Eminaga, Okyaz UNSPECIFIED UNSPECIFIED UNSPECIFIED Hinkelammert, Reemt UNSPECIFIED UNSPECIFIED UNSPECIFIED Abbas, Mahmoud UNSPECIFIED UNSPECIFIED UNSPECIFIED Woetzel, Fabian UNSPECIFIED UNSPECIFIED UNSPECIFIED Eltze, Elke UNSPECIFIED UNSPECIFIED UNSPECIFIED Bettendorf, Olaf UNSPECIFIED UNSPECIFIED UNSPECIFIED Boegemann, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Semjonow, Axel UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-390296
DOI:	10.1016/j.urology.2015.07.029
Journal or Publication Title:	Urology
Volume:	86
Number:	4
Page Range:	S. 798 - 805
Date:	2015
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1527-9995
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RADICAL PROSTATECTOMY; TUMOR VOLUME; BIOPSY; RISK; FEATURES; TRENDS; TRIAL; MEN; MAP Multiple languages Urology & Nephrology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/39029