Universität zu Köln

Heck, Angela ORCID: 0000-0002-1543-3197, Fastenrath, Matthias, Coynel, David ORCID: 0000-0001-5028-5807, Auschra, Bianca, Bickel, Horst, Freytag, Virginie, Gschwind, Leo, Hartmann, Francina, Jessen, Frank, Kaduszkiewicz, Hanna, Maier, Wolfgang, Milnik, Annette ORCID: 0000-0002-3933-3289, Pentzek, Michael, Riedel-Heller, Steffi G., Spalek, Klara ORCID: 0000-0002-4244-6495, Vogler, Christian, Wagner, Michael ORCID: 0000-0003-2589-6440, Weyerer, Siegfried, Wolfsgruber, Steffen, de Quervain, Dominique J. -F. and Papassotiropoulos, Andreas ORCID: 0000-0002-2210-9651 (2015). Genetic Analysis of Association Between Calcium Signaling and Hippocampal Activation, Memory Performance in the Young and Old, and Risk for Sporadic Alzheimer Disease. JAMA Psychiatry, 72 (10). S. 1029 - 1037. CHICAGO: AMER MEDICAL ASSOC. ISSN 2168-6238

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Abstract

IMPORTANCE Human episodic memory performance is linked to the function of specific brain regions, including the hippocampus; declines as a result of increasing age; and is markedly disturbed in Alzheimer disease (AD), an age-associated neurodegenerative disorder that primarily affects the hippocampus. Exploring the molecular underpinnings of human episodic memory is key to the understanding of hippocampus-dependent cognitive physiology and pathophysiology. OBJECTIVE To determine whether biologically defined groups of genes are enriched in episodic memory performance across age, memory encoding-related brain activity, and AD. DESIGN, SETTING, AND PARTICIPANTS In this multicenter collaborative study, which began in August 2008 and is ongoing, gene set enrichment analysis was done by using primary and meta-analysis data from 57 968 participants. The Swiss cohorts consisted of 3043 healthy young adults assessed for episodic memory performance. In a subgroup (n = 1119) of one of these cohorts, functional magnetic resonance imaging was used to identify gene set-dependent differences in brain activity related to episodic memory. The German Study on Aging, Cognition, and Dementia in Primary Care Patients cohort consisted of 763 elderly participants without dementia who were assessed for episodic memory performance. The International Genomics of Alzheimer's Project case-control sample consisted of 54 162 participants (17 008 patients with sporadic AD and 37 154 control participants). Analyses were conducted between January 2014 and June 2015. Gene set enrichment analysis in all samples was done using genome-wide single-nucleotide polymorphism data. MAIN OUTCOMES AND MEASURES Episodic memory performance in the Swiss cohort and German Study on Aging, Cognition, and Dementia in Primary Care Patients cohort was quantified by picture and verbal delayed free recall tasks. In the functional magnetic resonance imaging experiment, activation of the hippocampus during encoding of pictures served as the phenotype of interest. In the International Genomics of Alzheimer's Project sample, diagnosis of sporadic AD served as the phenotype of interest. RESULTS In the discovery sample, we detected significant enrichment for genes constituting the calcium signaling pathway, especially those related to the elevation of cytosolic calcium (P = 2 x 10(-4)). This enrichment was replicated in 2 additional samples of healthy young individuals (P = .02 and .04, respectively) and a sample of healthy elderly participants (P = .004). Hippocampal activation (P = 4 x 10(-4)) and the risk for sporadic AD (P = .01) were also significantly enriched for genes related to the elevation of cytosolic calcium. CONCLUSIONS AND RELEVANCE By detecting consistent significant enrichment in independent cohorts of young and elderly participants, this study identified that calcium signaling plays a central role in hippocampus-dependent human memory processes in cognitive health and disease, contributing to the understanding and potential treatment of hippocampus-dependent cognitive pathology.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Heck, Angela UNSPECIFIED orcid.org/0000-0002-1543-3197 UNSPECIFIED Fastenrath, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Coynel, David UNSPECIFIED orcid.org/0000-0001-5028-5807 UNSPECIFIED Auschra, Bianca UNSPECIFIED UNSPECIFIED UNSPECIFIED Bickel, Horst UNSPECIFIED UNSPECIFIED UNSPECIFIED Freytag, Virginie UNSPECIFIED UNSPECIFIED UNSPECIFIED Gschwind, Leo UNSPECIFIED UNSPECIFIED UNSPECIFIED Hartmann, Francina UNSPECIFIED UNSPECIFIED UNSPECIFIED Jessen, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Kaduszkiewicz, Hanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Maier, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Milnik, Annette UNSPECIFIED orcid.org/0000-0002-3933-3289 UNSPECIFIED Pentzek, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Riedel-Heller, Steffi G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Spalek, Klara UNSPECIFIED orcid.org/0000-0002-4244-6495 UNSPECIFIED Vogler, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Wagner, Michael UNSPECIFIED orcid.org/0000-0003-2589-6440 UNSPECIFIED Weyerer, Siegfried UNSPECIFIED UNSPECIFIED UNSPECIFIED Wolfsgruber, Steffen UNSPECIFIED UNSPECIFIED UNSPECIFIED de Quervain, Dominique J. -F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Papassotiropoulos, Andreas UNSPECIFIED orcid.org/0000-0002-2210-9651 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-391257
DOI:	10.1001/jamapsychiatry.2015.1309
Journal or Publication Title:	JAMA Psychiatry
Volume:	72
Number:	10
Page Range:	S. 1029 - 1037
Date:	2015
Publisher:	AMER MEDICAL ASSOC
Place of Publication:	CHICAGO
ISSN:	2168-6238
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LONG-TERM DEPRESSION; GENOME-WIDE; EPISODIC MEMORY; COGNITIVE-ABILITIES; PATHWAY ANALYSIS; AGE; POTENTIATION; NEUROSCIENCE; IMPAIRMENT; MECHANISMS Multiple languages Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/39125