Universität zu Köln

Ahmad, Wael, Majd, Payman, Luebke, Thomas, Aleksic, Marco and Brunkwall, Jan Sigge (2015). The presence of variant genotype of the mannose-binding lectin gene (MBL2) is not associated with increased restenosis rate in carotid surgery. J. Vasc. Surg., 62 (4). S. 946 - 951. NEW YORK: MOSBY-ELSEVIER. ISSN 0741-5214

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Abstract

Background: We investigated the role of mannose-binding lectin (MBL) variant genotypes in patients with significant carotid restenosis after carotid endarterectomy (CEA) and who underwent a revision CEA. Methods: This was a cross-sectional analysis of 97 patients enrolled between 2001 and 2013. Three groups were investigated: group A included patients with internal carotid artery restenosis, group B included patients without restenosis after CEA, and group C included patients with peripheral arterial disease but without any signs of a carotid stenosis. Venous blood samples were drawn for the genotyping for MBL2 by polymerase chain reaction and for the determination of the MBL serum concentration by enzyme-linked immunoabsorbent assay. Results: The serum concentration of MBL was higher in patients with the normal genotype than in those with the genotype variants of MBL (95% confidence interval, 272.8-1008.7 mu g/L; P = .001). There was no statistically significant difference among groups A, B, or C with respect to the presence of a variant genotype. Similarly, there was no significant gender difference regarding the presence of a variant genotype (P = .325). Conclusions: The presence of a variant genotype of the MBL2 gene (and the correspondingly lower serum concentration of this molecule) was not correlated with the development of carotid restenosis after CEA beyond a follow-up of 12 months.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ahmad, Wael UNSPECIFIED UNSPECIFIED UNSPECIFIED Majd, Payman UNSPECIFIED UNSPECIFIED UNSPECIFIED Luebke, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Aleksic, Marco UNSPECIFIED UNSPECIFIED UNSPECIFIED Brunkwall, Jan Sigge UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-391739
DOI:	10.1016/j.jvs.2014.02.063
Journal or Publication Title:	J. Vasc. Surg.
Volume:	62
Number:	4
Page Range:	S. 946 - 951
Date:	2015
Publisher:	MOSBY-ELSEVIER
Place of Publication:	NEW YORK
ISSN:	0741-5214
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ENDARTERECTOMY; STENOSIS; PROTEIN; CHROMOSOME-10; DEFICIENCY; STROKE; SERUM; DNA Multiple languages Surgery; Peripheral Vascular Disease Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/39173