Buyandelger, Byambajav, Mansfield, Catherine ORCID: 0000-0002-5063-5181, Kostin, Sawa, Choi, Onjee, Roberts, Angharad M., Ware, James S., Mazzarotto, Francesco ORCID: 0000-0002-6159-9980, Pesce, Francesco ORCID: 0000-0002-2882-4226, Buchan, Rachel, Isaacson, Rivka L., Vouffo, Josee, Gunkel, Sylvia, Knoll, Gudrun, McSweeney, Sara J., Wei, Heming, Perrot, Andreas ORCID: 0000-0002-8800-342X, Pfeiffer, Conny, Toliat, Mohammad Reza, Ilieva, Kristina, Krysztofinska, Ewelina, Lopez-Olaneta, Marina M., Gomez-Salinero, Jesus M., Schmidt, Albrecht, Ng, Keat-Eng, Teucher, Niels, Chen, Ju, Teichmann, Martin ORCID: 0000-0002-5257-0510, Eilers, Martin ORCID: 0000-0002-0376-6533, Haverkamp, Wilhelm, Regitz-Zagrosek, Vera, Hasenfuss, Gerd, Braun, Thomas ORCID: 0000-0002-6165-4804, Pennell, Dudley J., Gould, Ian, Barton, Paul J. R., Lara-Pezzi, Enrique ORCID: 0000-0002-2743-1033, Schaefer, Sebastian, Huebner, Norbert, Felkin, Leanne E., O'Regan, Declan P., Brand, Thomas, Milting, Hendrik, Nuernberg, Peter, Schneider, Michael D., Prasad, Sanjay, Petretto, Enrico and Knoll, Ralph (2015). ZBTB17 (MIZ1) Is Important for the Cardiac Stress Response and a Novel Candidate Gene for Cardiomyopathy and Heart Failure. Circ.-Cardiovasc. Genet., 8 (5). S. 643 - 653. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1942-3268

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Abstract

Background Mutations in sarcomeric and cytoskeletal proteins are a major cause of hereditary cardiomyopathies, but our knowledge remains incomplete as to how the genetic defects execute their effects. Methods and Results We used cysteine and glycine-rich protein 3, a known cardiomyopathy gene, in a yeast 2-hybrid screen and identified zinc-finger and BTB domain-containing protein 17 (ZBTB17) as a novel interacting partner. ZBTB17 is a transcription factor that contains the peak association signal (rs10927875) at the replicated 1p36 cardiomyopathy locus. ZBTB17 expression protected cardiac myocytes from apoptosis in vitro and in a mouse model with cardiac myocyte-specific deletion of Zbtb17, which develops cardiomyopathy and fibrosis after biomechanical stress. ZBTB17 also regulated cardiac myocyte hypertrophy in vitro and in vivo in a calcineurin-dependent manner. Conclusions We revealed new functions for ZBTB17 in the heart, a transcription factor that may play a role as a novel cardiomyopathy gene.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Buyandelger, ByambajavUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mansfield, CatherineUNSPECIFIEDorcid.org/0000-0002-5063-5181UNSPECIFIED
Kostin, SawaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Choi, OnjeeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roberts, Angharad M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ware, James S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mazzarotto, FrancescoUNSPECIFIEDorcid.org/0000-0002-6159-9980UNSPECIFIED
Pesce, FrancescoUNSPECIFIEDorcid.org/0000-0002-2882-4226UNSPECIFIED
Buchan, RachelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Isaacson, Rivka L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vouffo, JoseeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gunkel, SylviaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Knoll, GudrunUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
McSweeney, Sara J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wei, HemingUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Perrot, AndreasUNSPECIFIEDorcid.org/0000-0002-8800-342XUNSPECIFIED
Pfeiffer, ConnyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Toliat, Mohammad RezaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ilieva, KristinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krysztofinska, EwelinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lopez-Olaneta, Marina M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gomez-Salinero, Jesus M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmidt, AlbrechtUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ng, Keat-EngUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Teucher, NielsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chen, JuUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Teichmann, MartinUNSPECIFIEDorcid.org/0000-0002-5257-0510UNSPECIFIED
Eilers, MartinUNSPECIFIEDorcid.org/0000-0002-0376-6533UNSPECIFIED
Haverkamp, WilhelmUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Regitz-Zagrosek, VeraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hasenfuss, GerdUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Braun, ThomasUNSPECIFIEDorcid.org/0000-0002-6165-4804UNSPECIFIED
Pennell, Dudley J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gould, IanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barton, Paul J. R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lara-Pezzi, EnriqueUNSPECIFIEDorcid.org/0000-0002-2743-1033UNSPECIFIED
Schaefer, SebastianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Huebner, NorbertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Felkin, Leanne E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
O'Regan, Declan P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brand, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Milting, HendrikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nuernberg, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schneider, Michael D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Prasad, SanjayUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Petretto, EnricoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Knoll, RalphUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-391912
DOI: 10.1161/CIRCGENETICS.113.000690
Journal or Publication Title: Circ.-Cardiovasc. Genet.
Volume: 8
Number: 5
Page Range: S. 643 - 653
Date: 2015
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Place of Publication: PHILADELPHIA
ISSN: 1942-3268
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
MUSCLE LIM PROTEIN; DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; MUTATIONS; EXPRESSION; PATHWAY; PHOSPHORYLATION; DISRUPTION; APOPTOSIS; VARIANTMultiple languages
Cardiac & Cardiovascular Systems; Genetics & HeredityMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/39191

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