Universität zu Köln

Lohmann, Philipp ORCID: 0000-0002-5360-046X, Herzog, Hans, Rota Kops, Elena, Stoffels, Gabriele ORCID: 0000-0001-7114-1941, Judov, Natalie ORCID: 0000-0002-3909-9306, Filss, Christian ORCID: 0000-0002-9927-6335, Galldiks, Norbert ORCID: 0000-0002-2485-1796, Tellmann, Lutz ORCID: 0000-0002-1154-2847, Weiss, Carolin, Sabel, Michael, Coenen, Heinz Hubert, Shah, Nadim Jon and Langen, Karl-Josef ORCID: 0000-0003-1101-5075 (2015). Dual-time-point O-(2-[F-18]fluoroethyl)-L-tyrosine PET for grading of cerebral gliomas. Eur. Radiol., 25 (10). S. 3017 - 3025. NEW YORK: SPRINGER. ISSN 1432-1084

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Abstract

We aimed to evaluate the diagnostic potential of dual-time-point imaging with positron emission tomography (PET) using O-(2-[F-18]fluoroethyl)-L-tyrosine (F-18-FET) for non-invasive grading of cerebral gliomas compared with a dynamic approach. Thirty-six patients with histologically confirmed cerebral gliomas (21 primary, 15 recurrent; 24 high-grade, 12 low-grade) underwent dynamic PET from 0 to 50 min post-injection (p.i.) of F-18-FET, and additionally from 70 to 90 min p.i. Mean tumour-to-brain ratios (TBRmean) of F-18-FET uptake were determined in early (20-40 min p.i.) and late (70-90 min p.i.) examinations. Time-activity curves (TAC) of the tumours from 0 to 50 min after injection were assigned to different patterns. The diagnostic accuracy of changes of F-18-FET uptake between early and late examinations for tumour grading was compared to that of curve pattern analysis from 0 to 50 min p.i. of F-18-FET. The diagnostic accuracy of changes of the TBRmean of F-18-FET PET uptake between early and late examinations for the identification of HGG was 81 % (sensitivity 83 %; specificity 75 %; cutoff - 8 %; p < 0.001), and 83 % for curve pattern analysis (sensitivity 88 %; specificity 75 %; p < 0.001). Dual-time-point imaging of F-18-FET uptake in gliomas achieves diagnostic accuracy for tumour grading that is similar to the more time-consuming dynamic data acquisition protocol. Dual-time-point imaging is equivalent to dynamic FET PET for grading of gliomas. Dual-time-point imaging is less time consuming than dynamic FET PET. Costs can be reduced due to higher patient throughput. Reduced imaging time increases patient comfort and sedation might be avoided. Quicker image interpretation is possible, as no curve evaluation is necessary.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lohmann, Philipp UNSPECIFIED orcid.org/0000-0002-5360-046X UNSPECIFIED Herzog, Hans UNSPECIFIED UNSPECIFIED UNSPECIFIED Rota Kops, Elena UNSPECIFIED UNSPECIFIED UNSPECIFIED Stoffels, Gabriele UNSPECIFIED orcid.org/0000-0001-7114-1941 UNSPECIFIED Judov, Natalie UNSPECIFIED orcid.org/0000-0002-3909-9306 UNSPECIFIED Filss, Christian UNSPECIFIED orcid.org/0000-0002-9927-6335 UNSPECIFIED Galldiks, Norbert UNSPECIFIED orcid.org/0000-0002-2485-1796 UNSPECIFIED Tellmann, Lutz UNSPECIFIED orcid.org/0000-0002-1154-2847 UNSPECIFIED Weiss, Carolin UNSPECIFIED UNSPECIFIED UNSPECIFIED Sabel, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Coenen, Heinz Hubert UNSPECIFIED UNSPECIFIED UNSPECIFIED Shah, Nadim Jon UNSPECIFIED UNSPECIFIED UNSPECIFIED Langen, Karl-Josef UNSPECIFIED orcid.org/0000-0003-1101-5075 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-392003
DOI:	10.1007/s00330-015-3691-6
Journal or Publication Title:	Eur. Radiol.
Volume:	25
Number:	10
Page Range:	S. 3017 - 3025
Date:	2015
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1432-1084
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language O-(2-F-18-FLUOROETHYL)-L-TYROSINE PET; UPTAKE KINETICS; F-18-FET PET; BRAIN-TUMOR; FET PET; DIAGNOSIS; SPECT Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/39200