Universität zu Köln

Teipel, Stefan, Drzezga, Alexander, Grothe, Michel J. ORCID: 0000-0003-2600-9022, Barthel, Henryk, Chetelat, Gale, Schuff, Norbert, Skudlarski, Pawel, Cavedo, Enrica, Frisoni, Giovanni B., Hoffmann, Wolfgang, Thyrian, Jochen Rene ORCID: 0000-0001-6889-693X, Fox, Chris ORCID: 0000-0001-9480-5704, Minoshima, Satoshi ORCID: 0000-0002-0043-3047, Sabri, Osama ORCID: 0000-0002-6425-3504 and Fellgiebel, Andreas (2015). Multimodal imaging in Alzheimer's disease: validity and usefulness for early detection. Lancet Neurol., 14 (10). S. 1037 - 1054. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1474-4465

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Abstract

Alzheimer's disease is a progressive neurodegenerative disease that typically manifests clinically as an isolated amnestic deficit that progresses to a characteristic dementia syndrome. Advances in neuroimaging research have enabled mapping of diverse molecular, functional, and structural aspects of Alzheimer's disease pathology in ever increasing temporal and regional detail. Accumulating evidence suggests that distinct types of imaging abnormalities related to Alzheimer's disease follow a consistent trajectory during pathogenesis of the disease, and that the first changes can be detected years before the disease manifests clinically. These findings have fuelled clinical interest in the use of specific imaging markers for Alzheimer's disease to predict future development of dementia in patients who are at risk. The potential clinical usefulness of single or multimodal imaging markers is being investigated in selected patient samples from clinical expert centres, but additional research is needed before these promising imaging markers can be successfully translated from research into clinical practice in routine care.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Teipel, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Drzezga, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Grothe, Michel J. UNSPECIFIED orcid.org/0000-0003-2600-9022 UNSPECIFIED Barthel, Henryk UNSPECIFIED UNSPECIFIED UNSPECIFIED Chetelat, Gale UNSPECIFIED UNSPECIFIED UNSPECIFIED Schuff, Norbert UNSPECIFIED UNSPECIFIED UNSPECIFIED Skudlarski, Pawel UNSPECIFIED UNSPECIFIED UNSPECIFIED Cavedo, Enrica UNSPECIFIED UNSPECIFIED UNSPECIFIED Frisoni, Giovanni B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoffmann, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Thyrian, Jochen Rene UNSPECIFIED orcid.org/0000-0001-6889-693X UNSPECIFIED Fox, Chris UNSPECIFIED orcid.org/0000-0001-9480-5704 UNSPECIFIED Minoshima, Satoshi UNSPECIFIED orcid.org/0000-0002-0043-3047 UNSPECIFIED Sabri, Osama UNSPECIFIED orcid.org/0000-0002-6425-3504 UNSPECIFIED Fellgiebel, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-392157
DOI:	10.1016/S1474-4422(15)00093-9
Journal or Publication Title:	Lancet Neurol.
Volume:	14
Number:	10
Page Range:	S. 1037 - 1054
Date:	2015
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1474-4465
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MILD COGNITIVE IMPAIRMENT; POSITRON-EMISSION-TOMOGRAPHY; TEMPORAL-LOBE ATROPHY; PITTSBURGH COMPOUND-B; FIBRILLAR AMYLOID-BETA; SHORT-TERM CONVERSION; CEREBROSPINAL-FLUID; HIPPOCAMPAL VOLUME; FOLLOW-UP; PROBABILISTIC PREDICTION Multiple languages Clinical Neurology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/39215