Universität zu Köln

Schoenberger, Anna R., Hagelweide, Klara, Pelzer, Esther A., Fink, Gereon R. ORCID: 0000-0002-8230-1856 and Schubotz, Ricarda I. (2015). Motor loop dysfunction causes impaired cognitive sequencing in patients suffering from Parkinson's disease. Neuropsychologia, 77. S. 409 - 421. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD. ISSN 1873-3514

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Abstract

Cognitive impairment in Parkinson's disease (PD) is often attributed to dopamine deficiency in the prefrontal-basal ganglia thalamo-cortical loops. Although recent studies point to a close interplay between motor and cognitive abilities in PD, the so-called motor loop connecting supplementary motor area (SMA) and putamen has been considered solely with regard to the patients' motor impairment. Our study challenges this view by testing patients with the serial prediction task (SPT), a cognitive task that requires participants to predict stimulus sequences and particularly engages premotor sites of the motor loop. We hypothesised that affection of the motor loop causes impaired SPT performance, especially when the internal sequence representation is challenged by suspension of external stimuli. As shown for motor tasks, we further expected this impairment to be compensated by hyperactivity of the lateral premotor cortex (PM). We tested 16 male PD patients ON and OFF dopaminergic medication and 16 male age-matched healthy controls in an functional Magnetic Resonance Imaging study. All subjects performed two versions of the SPT: one with on-going sequences (SPTO), and one with sequences containing non-informative wildcards (SPT+) increasing the demands on mnemonic sequence representation. Patients ON (compared to controls) revealed an impaired performance coming along with hypoactivity of SMA and putamen. Patients OFF compared to ON medication, while showing poorer performance, exhibited a significantly increased PM activity for SPT+ vs. SPTO. Furthermore, patients' performance positively covaried with PM activity, corroborating a compensatory account. Our data reveal a contribution of the motor loop to cognitive impairment in PD, and suggest a close interplay of SMA and PM beyond motor control. (C) 2015 Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schoenberger, Anna R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hagelweide, Klara UNSPECIFIED UNSPECIFIED UNSPECIFIED Pelzer, Esther A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Schubotz, Ricarda I. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-392253
DOI:	10.1016/j.neuropsychologia.2015.09.017
Journal or Publication Title:	Neuropsychologia
Volume:	77
Page Range:	S. 409 - 421
Date:	2015
Publisher:	PERGAMON-ELSEVIER SCIENCE LTD
Place of Publication:	OXFORD
ISSN:	1873-3514
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language EXECUTIVE DYSFUNCTION; PRE-SUPPLEMENTARY; NEURONAL-ACTIVITY; LATERAL PREMOTOR; BASAL GANGLIA; MOVEMENTS; GAIT; DEMENTIA; DEFICITS; SYSTEM Multiple languages Behavioral Sciences; Neurosciences; Psychology, Experimental Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/39225