Universität zu Köln

Pechmann, Matthias, Schwager, Evelyn E., Turetzek, Natascha and Prpic, Nikola-Michael (2015). Regressive evolution of the arthropod tritocerebral segment linked to functional divergence of the Hox gene. Proc. R. Soc. B-Biol. Sci., 282 (1814). S. 206 - 212. LONDON: ROYAL SOC. ISSN 1471-2954

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Abstract

The intercalary segment is a limbless version of the tritocerebral segment and is present in the head of all insects, whereas other extant arthropods have retained limbs on their tritocerebral segment (e.g. the pedipalp limbs in spiders). The evolutionary origin of limb loss on the intercalary segment has puzzled zoologists for over a century. Here we show that an intercalary segment-like phenotype can be created in spiders by interfering with the function of the Hox gene labial. This links the origin of the intercalary segment to a functional change in labial. We show that in the spider Parasteatoda tepidariorum the labial gene has two functions: one function in head tissue maintenance that is conserved between spiders and insects, and a second function in pedipalp limb promotion and specification, which is only present in spiders. These results imply that labial was originally crucial for limb formation on the tritocerebral segment, but that it has lost this particular subf unction in the insect ancestor, resulting in limb loss on the intercalary segment. Such loss of a sub-function is a way to avoid adverse pleiotropic effects normally associated with mutations in developmental genes, and may thus be a common mechanism to accelerate regressive evolution.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Pechmann, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Schwager, Evelyn E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Turetzek, Natascha UNSPECIFIED UNSPECIFIED UNSPECIFIED Prpic, Nikola-Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-393153
DOI:	10.1098/rspb.2015.1162
Journal or Publication Title:	Proc. R. Soc. B-Biol. Sci.
Volume:	282
Number:	1814
Page Range:	S. 206 - 212
Date:	2015
Publisher:	ROYAL SOC
Place of Publication:	LONDON
ISSN:	1471-2954
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HEAD SEGMENTATION; SPIDER; EXPRESSION; ONYCHOPHORAN; CAVEFISH Multiple languages Biology; Ecology; Evolutionary Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/39315