Templin, C., Ghadri, J. R., Diekmann, J., Napp, L. C., Bataiosu, D. R., Jaguszewski, M., Cammann, V. L., Sarcon, A., Geyer, V., Neumann, C. A., Seifert, B., Hellermann, J., Schwyzer, M., Eisenhardt, K., Jenewein, J., Franke, J., Katus, H. A., Burgdorf, C., Schunkert, H., Moeller, C., Thiele, H., Bauersachs, J., Tschoepe, C., Schultheiss, H-P., Laney, C. A., Rajan, L., Michels, G., Pfister, R., Ukena, C., Boehm, M., Erbel, R., Cuneo, A., Kuck, K-H., Jacobshagen, C., Hasenfuss, G., Karakas, M., Koenig, W., Rottbauer, W., Said, S. M., Braun-Dullaeus, R. C., Cuculi, F., Banning, A., Fischer, T. A., Vasankari, T., Airaksinen, K. E. J., Fijalkowski, M., Rynkiewicz, A., Pawlak, M., Opolski, G., Dworakowski, R., MacCarthy, P., Kaiser, C., Osswald, S., Galiuto, L., Crea, F., Dichtl, W., Franz, W. M., Empen, K., Felix, S. B., Delmas, C., Lairez, O., Erne, P., Bax, J. J., Ford, I., Ruschitzka, F., Prasad, A. and Luescher, T. F. (2015). Clinical Features and Outcomes of Takotsubo (Stress) Cardiomyopathy. N. Engl. J. Med., 373 (10). S. 929 - 939. WALTHAM: MASSACHUSETTS MEDICAL SOC. ISSN 1533-4406

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Abstract

BACKGROUND The natural history, management, and outcome of takotsubo (stress) cardiomyopathy are incompletely understood. METHODS The International Takotsubo Registry, a consortium of 26 centers in Europe and the United States, was established to investigate clinical features, prognostic predictors, and outcome of takotsubo cardiomyopathy. Patients were compared with age- and sex-matched patients who had an acute coronary syndrome. RESULTS Of 1750 patients with takotsubo cardiomyopathy, 89.8% were women (mean age, 66.8 years). Emotional triggers were not as common as physical triggers (27.7% vs. 36.0%), and 28.5% of patients had no evident trigger. Among patients with takotsubo cardiomyopathy, as compared with an acute coronary syndrome, rates of neurologic or psychiatric disorders were higher (55.8% vs. 25.7%) and the mean left ventricular ejection fraction was markedly lower (40.7 +/- 11.2% vs. 51.5 +/- 12.3%) (P < 0.001 for both comparisons). Rates of severe in-hospital complications including shock and death were similar in the two groups (P = 0.93). Physical triggers, acute neurologic or psychiatric diseases, high troponin levels, and a low ejection fraction on admission were independent predictors for in-hospital complications. During long-term follow-up, the rate of major adverse cardiac and cerebrovascular events was 9.9% per patient-year, and the rate of death was 5.6% per patient-year. CONCLUSIONS Patients with takotsubo cardiomyopathy had a higher prevalence of neurologic or psychiatric disorders than did those with an acute coronary syndrome. This condition represents an acute heart failure syndrome with substantial morbidity and mortality. (Funded by the Mach-Gaensslen Foundation and others; ClinicalTrials.gov number, NCT01947621.)

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Templin, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ghadri, J. R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Diekmann, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Napp, L. C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bataiosu, D. R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jaguszewski, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cammann, V. L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sarcon, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Geyer, V.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neumann, C. A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seifert, B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hellermann, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schwyzer, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eisenhardt, K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jenewein, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Franke, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Katus, H. A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Burgdorf, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schunkert, H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moeller, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thiele, H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bauersachs, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tschoepe, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schultheiss, H-P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Laney, C. A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rajan, L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Michels, G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pfister, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ukena, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boehm, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Erbel, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cuneo, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kuck, K-H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jacobshagen, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hasenfuss, G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Karakas, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koenig, W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rottbauer, W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Said, S. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Braun-Dullaeus, R. C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cuculi, F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Banning, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fischer, T. A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vasankari, T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Airaksinen, K. E. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fijalkowski, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rynkiewicz, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pawlak, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Opolski, G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dworakowski, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
MacCarthy, P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaiser, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Osswald, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Galiuto, L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Crea, F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dichtl, W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Franz, W. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Empen, K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Felix, S. B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Delmas, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lairez, O.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Erne, P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bax, J. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ford, I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruschitzka, F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Prasad, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Luescher, T. F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-393191
DOI: 10.1056/NEJMoa1406761
Journal or Publication Title: N. Engl. J. Med.
Volume: 373
Number: 10
Page Range: S. 929 - 939
Date: 2015
Publisher: MASSACHUSETTS MEDICAL SOC
Place of Publication: WALTHAM
ISSN: 1533-4406
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
TAKO-TSUBO CARDIOMYOPATHY; APICAL BALLOONING SYNDROME; ACUTE MYOCARDIAL-INFARCTION; CORONARY-ARTERY STENOSIS; HEART; DYSFUNCTIONMultiple languages
Medicine, General & InternalMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/39319

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