Baum, Thomas ORCID: 0000-0002-4574-5212, Karampinos, Dimitrios C., Brockow, Knut, Seifert-Klauss, Vanadin, Jungmann, Pia M., Biedermann, Tilo ORCID: 0000-0002-5352-5105, Rummeny, Ernst J., Bauer, Jan S. and Mueller, Dirk (2015). MR-based trabecular bone microstructure is not altered in subjects with indolent systemic mastocytosis. Clin. Imaging, 39 (5). S. 886 - 890. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1873-4499

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Abstract

Subjects with indolent systemic mastocytosis (ISM) have an increased risk for osteoporosis. It has been demonstrated that trabecular bone microstructure analysis improves the prediction of bone strength beyond dual-energy X-ray absorptiometry-based bone mineral density. The purpose of this study was to obtain Magnetic Resonance (MR)-based trabecular bone microstructure parameters as advanced imaging biomarkers in subjects with ISM (n=18) and compare them with those of normal controls (n=18). Trabecular bone microstructure parameters were not significantly (P>.05) different between subjects with ISM and controls. These findings revealed important pathophysiological information about ISM-associated osteoporosis and may limit the use of trabecular bone microstructure analysis in this clinical setting. (C) 2015 Elsevier Inc. All rights reserved.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Baum, ThomasUNSPECIFIEDorcid.org/0000-0002-4574-5212UNSPECIFIED
Karampinos, Dimitrios C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brockow, KnutUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seifert-Klauss, VanadinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jungmann, Pia M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Biedermann, TiloUNSPECIFIEDorcid.org/0000-0002-5352-5105UNSPECIFIED
Rummeny, Ernst J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bauer, Jan S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mueller, DirkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-394345
DOI: 10.1016/j.clinimag.2014.12.006
Journal or Publication Title: Clin. Imaging
Volume: 39
Number: 5
Page Range: S. 886 - 890
Date: 2015
Publisher: ELSEVIER SCIENCE INC
Place of Publication: NEW YORK
ISSN: 1873-4499
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
DISTAL RADIUS; MINERAL DENSITY; OSTEOPOROSIS; FRACTURES; STANDARDIZATION; ARCHITECTURE; DIAGNOSTICSMultiple languages
Radiology, Nuclear Medicine & Medical ImagingMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/39434

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