Universität zu Köln

Schoellhorn, Laura, Bock, Felix and Cursiefen, Claus (2015). Thrombospondin-1 as a Regulator of Corneal Inflammation and Lymphangiogenesis: Effects on Dry Eye Disease and Corneal Graft Immunology. J. Ocular Pharmacol. Ther., 31 (7). S. 376 - 386. NEW ROCHELLE: MARY ANN LIEBERT, INC. ISSN 1557-7732

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Abstract

Thrombospondin-1 (TSP-1) is a matricellular glycoprotein that belongs to a family of evolutionary highly conserved calcium-binding proteins consisting of 5 members (TSP-1-TSP-5). In the eye, TSP-1 is expressed by several ocular cell types and is also detectable in the aqueous humor and the vitreous body. So far, TSP-1 is one of the major activators of TGF beta, suggesting a strong influence on various important cellular functions and interactions such as differentiation, migration, and wound healing. TSP-1 is also a key endogenous inhibitor of hem- and lymphangiogenesis. Several lines of evidence indicate a crucial role of TSP-1 in maintaining the ocular immune and angiogenic privilege, for example, by regulating T lymphocytes and the tolerance-promoting properties of ocular antigen-presenting cells. This review discusses the role of TSP-1 in dry eye disease and corneal graft rejection through its effects on hem- and lymphangiogenesis, as well as on the underlying immune responses. Recent work will be reviewed showing by which molecular mechanism TSP-1 modulates inflammatory processes during ocular diseases. This opens potential new treatment avenues in inflammatory and (lymph)angiogenic ocular diseases.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schoellhorn, Laura UNSPECIFIED UNSPECIFIED UNSPECIFIED Bock, Felix UNSPECIFIED UNSPECIFIED UNSPECIFIED Cursiefen, Claus UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-394374
DOI:	10.1089/jop.2015.0020
Journal or Publication Title:	J. Ocular Pharmacol. Ther.
Volume:	31
Number:	7
Page Range:	S. 376 - 386
Date:	2015
Publisher:	MARY ANN LIEBERT, INC
Place of Publication:	NEW ROCHELLE
ISSN:	1557-7732
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ENDOTHELIAL GROWTH-FACTOR; ANTIGEN-PRESENTING CELLS; IMMUNE DEVIATION ACAID; OCULAR SURFACE INFLAMMATION; DRAINING LYMPH-NODES; T-CELLS; ANTERIOR-CHAMBER; SJOGRENS-SYNDROME; TGF-BETA; IN-VITRO Multiple languages Ophthalmology; Pharmacology & Pharmacy Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/39437