Luksys, Gediminas, Fastenrath, Matthias, Coynel, David ORCID: 0000-0001-5028-5807, Freytag, Virginie, Gschwind, Leo, Heck, Angela ORCID: 0000-0002-1543-3197, Jessen, Frank, Maier, Wolfgang, Milnik, Annette ORCID: 0000-0002-3933-3289, Riedel-Heller, Steffi G., Scherer, Martin, Spalek, Klara ORCID: 0000-0002-4244-6495, Vogler, Christian, Wagner, Michael ORCID: 0000-0003-2589-6440, Wolfsgruber, Steffen, Papassotiropoulos, Andreas ORCID: 0000-0002-2210-9651 and de Quervain, Dominique J. -F. (2015). Computational dissection of human episodic memory reveals mental process-specific genetic profiles. Proc. Natl. Acad. Sci. U. S. A., 112 (35). S. E4939 - 10. WASHINGTON: NATL ACAD SCIENCES. ISSN 0027-8424

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Abstract

Episodic memory performance is the result of distinct mental processes, such as learning, memory maintenance, and emotional modulation of memory strength. Such processes can be effectively dissociated using computational models. Here we performed gene set enrichment analyses of model parameters estimated from the episodic memory performance of 1,765 healthy young adults. We report robust and replicated associations of the amine compound SLC (solute-carrier) transporters gene set with the learning rate, of the collagen formation and transmembrane receptor protein tyrosine kinase activity gene sets with the modulation of memory strength by negative emotional arousal, and of the L1 cell adhesion molecule (L1CAM) interactions gene set with the repetition-based memory improvement. Furthermore, in a large functional MRI sample of 795 subjects we found that the association between L1CAM interactions and memory maintenance revealed large clusters of differences in brain activity in frontal cortical areas. Our findings provide converging evidence that distinct genetic profiles underlie specific mental processes of human episodic memory. They also provide empirical support to previous theoretical and neurobiological studies linking specific neuro-modulators to the learning rate and linking neural cell adhesion molecules to memory maintenance. Furthermore, our study suggests additional memory-related genetic pathways, which may contribute to a better understanding of the neurobiology of human memory.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Luksys, GediminasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fastenrath, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Coynel, DavidUNSPECIFIEDorcid.org/0000-0001-5028-5807UNSPECIFIED
Freytag, VirginieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gschwind, LeoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heck, AngelaUNSPECIFIEDorcid.org/0000-0002-1543-3197UNSPECIFIED
Jessen, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maier, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Milnik, AnnetteUNSPECIFIEDorcid.org/0000-0002-3933-3289UNSPECIFIED
Riedel-Heller, Steffi G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scherer, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spalek, KlaraUNSPECIFIEDorcid.org/0000-0002-4244-6495UNSPECIFIED
Vogler, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wagner, MichaelUNSPECIFIEDorcid.org/0000-0003-2589-6440UNSPECIFIED
Wolfsgruber, SteffenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Papassotiropoulos, AndreasUNSPECIFIEDorcid.org/0000-0002-2210-9651UNSPECIFIED
de Quervain, Dominique J. -F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-394580
DOI: 10.1073/pnas.1500860112
Journal or Publication Title: Proc. Natl. Acad. Sci. U. S. A.
Volume: 112
Number: 35
Page Range: S. E4939 - 10
Date: 2015
Publisher: NATL ACAD SCIENCES
Place of Publication: WASHINGTON
ISSN: 0027-8424
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
STRIATAL DOPAMINERGIC GENES; MILD COGNITIVE IMPAIRMENT; GENOME-WIDE ASSOCIATION; CELL-ADHESION MOLECULES; WORKING-MEMORY; ALZHEIMERS-DISEASE; HIPPOCAMPAL NEUROGENESIS; RECOGNITION MEMORY; PREFRONTAL CORTEX; NEUROSCIENCEMultiple languages
Multidisciplinary SciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/39458

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