Universität zu Köln

Floeck, A., Remig, I., Mueller, A., Nadal, J., Berg, C., Gembruch, U. and Geipel, Annegret (2015). Conflicting umbilical artery Doppler findings in fetuses with trisomy 21. Arch. Gynecol. Obstet., 292 (3). S. 613 - 618. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1432-0711

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Abstract

To assess differences between fetuses with isolated and non-isolated trisomy 21 in umbilical artery (UA) Doppler findings in the second and third trimester and to correlate those with placental histology. Retrospective analysis of UA pulsatility index (PI) in 281 fetuses with trisomy 21. Cases were divided into isolated trisomy 21 (group I, n = 148, 52.7 %) and non-isolated trisomy 21 (group II, n = 133, 47.3 %). UA measurements were evaluated in five different time periods (A-E; < 20 + 0 to a parts per thousand yen35 + 0 weeks) and were assigned histopathology of the placenta. In 118/281 (42 %) cases, UA measurement was abnormal. The frequency of PI values above the 95th percentile increased significantly with gestational age in both groups (period A 32.9 % vs. period E 63.6 %, p < 0.0001). There was neither a difference in abnormal UA PI values between isolated and non-isolated cases [37.8 % (56/148) vs. 46.6 % (62/133)] nor a correlation to placental findings. Fetuses with trisomy 21 often present with elevated UA PI in the late second or third trimester, irrespective of small for gestational age growth, malformations or histopathological findings of impaired placentation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Floeck, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Remig, I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Nadal, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Berg, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gembruch, U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Geipel, Annegret UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-394907
DOI:	10.1007/s00404-015-3703-4
Journal or Publication Title:	Arch. Gynecol. Obstet.
Volume:	292
Number:	3
Page Range:	S. 613 - 618
Date:	2015
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1432-0711
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INCREASED NUCHAL TRANSLUCENCY; PULSATILITY INDEX; 1ST TRIMESTER; DOWN-SYNDROME; EARLY PREGNANCIES; 20-YEAR TRENDS; MATERNAL AGE; WAVE-FORMS; PREVALENCE; VELOCITY Multiple languages Obstetrics & Gynecology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/39490