Universität zu Köln

Madelung, Ann B., Bondo, Henrik, Stamp, Inger, Lovgreen, Preben, Nielsen, Signe L., Falensteen, Anne, Knudsen, Helle, Svendsen, Kira D., Lange, Theis ORCID: 0000-0001-6807-8347, Ralfkiaer, Elisabeth, Nielsen, Karsten, Hasselbalch, Hans ORCID: 0000-0003-3936-8032 and Thiele, Juergen (2015). WHO classification 2008 of myeloproliferative neoplasms: a workshop learning effect - the Danish experience. APMIS, 123 (9). S. 787 - 793. HOBOKEN: WILEY. ISSN 1600-0463

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Abstract

We examined the learning effect of a workshop for Danish hematopathologists led by an international expert regarding histological subtyping of myeloproliferative neoplasms (MPN). Six hematopathologists evaluated 43 bone marrow (BM) biopsies according to the WHO description (2008), blinded to clinical data. All panelists then participated in the workshop. The case biopsies - mixed with 251 other MPN BM biopsies - were reviewed again. Consensus regarding the histological subtype was significantly improved; from 49% to 72% (Fleiss kappa value 0.302 pre-workshop, 0.474 post-workshop; p=0.004). There was no significant effect on the isolated morphological characteristics. Agreement between cases with histological consensus and clinical diagnosis was 86% without significant change during workshop sessions. Our study demonstrates that experienced hematopathologists can significantly improve their diagnostic ability by a workshop led by an international expert; not by improving the evaluation of individual histological parameters but by weighting these in their conclusive diagnosis.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Madelung, Ann B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bondo, Henrik UNSPECIFIED UNSPECIFIED UNSPECIFIED Stamp, Inger UNSPECIFIED UNSPECIFIED UNSPECIFIED Lovgreen, Preben UNSPECIFIED UNSPECIFIED UNSPECIFIED Nielsen, Signe L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Falensteen, Anne UNSPECIFIED UNSPECIFIED UNSPECIFIED Knudsen, Helle UNSPECIFIED UNSPECIFIED UNSPECIFIED Svendsen, Kira D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lange, Theis UNSPECIFIED orcid.org/0000-0001-6807-8347 UNSPECIFIED Ralfkiaer, Elisabeth UNSPECIFIED UNSPECIFIED UNSPECIFIED Nielsen, Karsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Hasselbalch, Hans UNSPECIFIED orcid.org/0000-0003-3936-8032 UNSPECIFIED Thiele, Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-395217
DOI:	10.1111/apm.12417
Journal or Publication Title:	APMIS
Volume:	123
Number:	9
Page Range:	S. 787 - 793
Date:	2015
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1600-0463
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language WORLD-HEALTH-ORGANIZATION; BONE-MARROW FIBROSIS; ESSENTIAL THROMBOCYTHEMIA; PRIMARY MYELOFIBROSIS; EUROPEAN CONSENSUS; DIAGNOSIS; RUXOLITINIB; PATHOLOGY; SURVIVAL; CRITERIA Multiple languages Immunology; Microbiology; Pathology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/39521