Universität zu Köln

Holtbernd, Florian, Ma, Yilong ORCID: 0000-0002-8383-6748, Peng, Shichun, Schwartz, Frank, Timmermann, Lars, Kracht, Lutz, Fink, Gereon R. ORCID: 0000-0002-8230-1856, Tang, Chris C., Eidelberg, David and Eggers, Carsten (2015). Dopaminergic correlates of metabolic network activity in Parkinson's disease. Hum. Brain Mapp., 36 (9). S. 3575 - 3586. HOBOKEN: WILEY. ISSN 1097-0193

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Abstract

Parkinson's disease (PD) is associated with distinct metabolic covariance patterns that relate to the motor and cognitive manifestations of the disorder. It is not known, however, how the expression of these patterns relates to measurements of nigrostriatal dopaminergic activity from the same individuals. To explore these associations, we studied 106 PD subjects who underwent cerebral PET with both F-18-fluorodeoxyglucose (FDG) and F-18-fluoro-L-dopa (FDOPA). Expression values for the PD motor- and cognition-related metabolic patterns (PDRP and PDCP, respectively) were computed for each subject; these measures were correlated with FDOPA uptake on a voxel-by-voxel basis. To explore the relationship between dopaminergic function and local metabolic activity, caudate and putamen FDOPA PET signal was correlated voxel-wise with FDG uptake over the entire brain. PDRP expression correlated with FDOPA uptake in caudate and putamen (P<0.001), while PDCP expression correlated with uptake in the anterior striatum (P<0.001). While statistically significant, the correlations were only of modest size, accounting for less than 20% of the overall variation in these measures. After controlling for PDCP expression, PDRP correlations were significant only in the posterior putamen. Of note, voxel-wise correlations between caudate/putamen FDOPA uptake and whole-brain FDG uptake were significant almost exclusively in PDRP regions. Overall, the data indicate that PDRP and PDCP expression correlates significantly with PET indices of presynaptic dopaminergic functioning obtained in the same individuals. Even so, the modest size of these correlations suggests that in PD patients, individual differences in network activity cannot be explained solely by nigrostriatal dopamine loss. Hum Brain Mapp 36:3575-3585, 2015. (c) 2015 Wiley Periodicals, Inc.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Holtbernd, Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED Ma, Yilong UNSPECIFIED orcid.org/0000-0002-8383-6748 UNSPECIFIED Peng, Shichun UNSPECIFIED UNSPECIFIED UNSPECIFIED Schwartz, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Timmermann, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED Kracht, Lutz UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Tang, Chris C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Eidelberg, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Eggers, Carsten UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-395524
DOI:	10.1002/hbm.22863
Journal or Publication Title:	Hum. Brain Mapp.
Volume:	36
Number:	9
Page Range:	S. 3575 - 3586
Date:	2015
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1097-0193
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SLEEP BEHAVIOR DISORDER; BRAIN NETWORKS; SUBTHALAMIC NUCLEUS; CAUDATE-NUCLEUS; BASAL GANGLIA; LEWY BODIES; DEMENTIA; PET; ABNORMALITIES; DYSFUNCTION Multiple languages Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/39552