Universität zu Köln

Wu, Pensee ORCID: 0000-0003-0011-5636, van den Berg, Caroline, Alfirevic, Zarko, O'Brien, Shaughn, Roethlisberger, Maria, Baker, Philip Newton, Kenny, Louise C., Kublickiene, Karolina ORCID: 0000-0002-4841-6836 and Duvekot, Johannes J. (2015). Early Pregnancy Biomarkers in Pre-Eclampsia: A Systematic Review and Meta-Analysis. Int. J. Mol. Sci., 16 (9). S. 23035 - 23057. BASEL: MDPI. ISSN 1422-0067

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Abstract

Pre-eclampsia (PE) complicates 2%-8% of all pregnancies and is an important cause of perinatal morbidity and mortality worldwide. In order to reduce these complications and to develop possible treatment modalities, it is important to identify women at risk of developing PE. The use of biomarkers in early pregnancy would allow appropriate stratification into high and low risk pregnancies for the purpose of defining surveillance in pregnancy and to administer interventions. We used formal methods for a systematic review and meta-analyses to assess the accuracy of all biomarkers that have been evaluated so far during the first and early second trimester of pregnancy to predict PE. We found low predictive values using individual biomarkers which included a disintegrin and metalloprotease 12 (ADAM-12), inhibin-A, pregnancy associated plasma protein A (PAPP-A), placental growth factor (PlGF) and placental protein 13 (PP-13). The pooled sensitivity of all single biomarkers was 0.40 (95% CI 0.39-0.41) at a false positive rate of 10%. The area under the Summary of Receiver Operating Characteristics Curve (SROC) was 0.786 (SE 0.02). When a combination model was used, the predictive value improved to an area under the SROC of 0.893 (SE 0.03). In conclusion, although there are multiple potential biomarkers for PE their efficacy has been inconsistent and comparisons are difficult because of heterogeneity between different studies. Therefore, there is an urgent need for high quality, large-scale multicentre research in biomarkers for PE so that the best predictive marker(s) can be identified in order to improve the management of women destined to develop PE.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wu, Pensee UNSPECIFIED orcid.org/0000-0003-0011-5636 UNSPECIFIED van den Berg, Caroline UNSPECIFIED UNSPECIFIED UNSPECIFIED Alfirevic, Zarko UNSPECIFIED UNSPECIFIED UNSPECIFIED O'Brien, Shaughn UNSPECIFIED UNSPECIFIED UNSPECIFIED Roethlisberger, Maria UNSPECIFIED UNSPECIFIED UNSPECIFIED Baker, Philip Newton UNSPECIFIED UNSPECIFIED UNSPECIFIED Kenny, Louise C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kublickiene, Karolina UNSPECIFIED orcid.org/0000-0002-4841-6836 UNSPECIFIED Duvekot, Johannes J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-395566
DOI:	10.3390/ijms160923035
Journal or Publication Title:	Int. J. Mol. Sci.
Volume:	16
Number:	9
Page Range:	S. 23035 - 23057
Date:	2015
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	1422-0067
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language UTERINE ARTERY DOPPLER; PLACENTAL GROWTH-FACTOR; 1ST TRIMESTER; PAPP-A; PULSATILITY INDEX; NULLIPAROUS WOMEN; PROTEIN 13; 1ST-TRIMESTER PREDICTION; MATERNAL CHARACTERISTICS; HYPERTENSIVE DISORDERS Multiple languages Biochemistry & Molecular Biology; Chemistry, Multidisciplinary Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/39556