Universität zu Köln

Ratheesh, Aswin, Cotton, Susan M., Betts, Jennifer K., Chanen, Andrew ORCID: 0000-0003-4468-622X, Nelson, Barnaby ORCID: 0000-0002-6263-2332, Davey, Christopher G., McGorry, Patrick D., Berk, Michael ORCID: 0000-0002-5554-6946 and Bechdolf, Andreas (2015). Prospective progression from high-prevalence disorders to bipolar disorder: Exploring characteristics of pre-illness stages. J. Affect. Disord., 183. S. 45 - 49. AMSTERDAM: ELSEVIER SCIENCE BV. ISSN 1573-2517

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Abstract

Background: identification of risk factors within precursor syndromes, such as depression, anxiety or substance use disorders (SUD), might help to pinpoint high-risk stages where preventive interventions for Bipolar Disorder (BD) could be evaluated. Methods: We examined baseline demographic, clinical, quality of lift, and temperament measures along with risk clusters among 52 young people seeking help for depression, anxiety or SUDs without psychosis or BD. The risk clusters included Bipolar At-Risk (BAR) and the Bipolarity index as measures of bipolarity and the Ultra-High Risk assessment for psychosis. The participants were followed up for 12 months to identify conversion to BD. Those who converted and did not convert to BD were compared using Chi-Square and Mann Whitney U tests. Results: The sample was predominantly female (85%) and a majority had prior treatment (64%). Four participants converted to BD over the 1-year follow up period. Having an alcohol use disorder at baseline (75% vs 8%, chi(2) = 14.1, p < 0.001) or a family history of SUD (67% vs 12.5%, chi(2)=6.0, p=0.01) were associated with development of BD. The sub threshold mania subgroup of BAR criteria was also associated with 12-month BD outcomes. The severity of depressive symptoms and cannabis use had high effects sizes of association with BD outcomes, without statistical significance. Conclusions and limitations: The small number of conversions limited the power of the study to identify associations with risk factors that have previously been reported to predict BD. However, subthreshold affective symptoms and SUDs might predict the onset of BD among help seeking young people with high-prevalence disorders. (C) 2015 Elsevier B.V. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ratheesh, Aswin UNSPECIFIED UNSPECIFIED UNSPECIFIED Cotton, Susan M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Betts, Jennifer K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Chanen, Andrew UNSPECIFIED orcid.org/0000-0003-4468-622X UNSPECIFIED Nelson, Barnaby UNSPECIFIED orcid.org/0000-0002-6263-2332 UNSPECIFIED Davey, Christopher G. UNSPECIFIED UNSPECIFIED UNSPECIFIED McGorry, Patrick D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Berk, Michael UNSPECIFIED orcid.org/0000-0002-5554-6946 UNSPECIFIED Bechdolf, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-395593
DOI:	10.1016/j.jad.2015.04.025
Journal or Publication Title:	J. Affect. Disord.
Volume:	183
Page Range:	S. 45 - 49
Date:	2015
Publisher:	ELSEVIER SCIENCE BV
Place of Publication:	AMSTERDAM
ISSN:	1573-2517
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HELP-SEEKING ADOLESCENTS; SUBSTANCE USE DISORDERS; MOOD DISORDERS; RATING-SCALE; YOUNG-ADULTS; VALIDATION; PREDICTORS; DEPRESSION; VALIDITY; MANIA Multiple languages Clinical Neurology; Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/39559