Clemen, Christoph S., Marko, Marija, Strucksberg, Karl-Heinz, Behrens, Juliane, Wittig, Ilka, Gaertner, Linda, Winter, Lilli ORCID: 0000-0002-6368-1160, Chevessier, Frederic, Matthias, Jan, Tuerk, Matthias, Tangavelou, Karthikeyan, Schuetz, Johanna, Arhzaouy, Khalid, Klopffleisch, Karsten, Hanisch, Franz-Georg, Rottbauer, Wolfgang, Bluemcke, Ingmar, Just, Steffen, Eichinger, Ludwig ORCID: 0000-0003-1594-6117, Hofmann, Andreas ORCID: 0000-0003-4408-5467 and Schroeder, Rolf (2015). VCP and PSMF1: Antagonistic regulators of proteasome activity. Biochem. Biophys. Res. Commun., 463 (4). S. 1210 - 1218. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE. ISSN 1090-2104

Full text not available from this repository.

Abstract

Protein turnover and quality control by the proteasome is of paramount importance for cell homeostasis. Dysfunction of the proteasome is associated with aging processes and human diseases such as neurodegeneration, cardiomyopathy, and cancer. The regulation, i.e. activation and inhibition of this fundamentally important protein degradation system, is still widely unexplored. We demonstrate here that the evolutionarily highly conserved type II triple-A ATPase VCP and the proteasome inhibitor PSMF1/PI31 interact directly, and antagonistically regulate proteasomal activity. Our data provide novel insights into the regulation of proteasomal activity. (C) 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/hy-nc-nd/4.0/).

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Clemen, Christoph S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marko, MarijaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Strucksberg, Karl-HeinzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Behrens, JulianeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wittig, IlkaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gaertner, LindaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Winter, LilliUNSPECIFIEDorcid.org/0000-0002-6368-1160UNSPECIFIED
Chevessier, FredericUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Matthias, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tuerk, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tangavelou, KarthikeyanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schuetz, JohannaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arhzaouy, KhalidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klopffleisch, KarstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hanisch, Franz-GeorgUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rottbauer, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bluemcke, IngmarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Just, SteffenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eichinger, LudwigUNSPECIFIEDorcid.org/0000-0003-1594-6117UNSPECIFIED
Hofmann, AndreasUNSPECIFIEDorcid.org/0000-0003-4408-5467UNSPECIFIED
Schroeder, RolfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-396573
DOI: 10.1016/j.bbrc.2015.06.086
Journal or Publication Title: Biochem. Biophys. Res. Commun.
Volume: 463
Number: 4
Page Range: S. 1210 - 1218
Date: 2015
Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE
Place of Publication: SAN DIEGO
ISSN: 1090-2104
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
VALOSIN-CONTAINING PROTEIN; CELLULAR ROLES; REVEALS; NETWORK; PI31; DEGRADATION; INHIBITOR; BINDING; PA28; ERADMultiple languages
Biochemistry & Molecular Biology; BiophysicsMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/39657

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item