Universität zu Köln

Dold, Leona, Ahlenstiel, Golo ORCID: 0000-0003-0026-1457, Althausen, Eva, Luda, Carolin, Schwarze-Zander, Carolynne, Boesecke, Christoph, Wasmuth, Jan-Christian, Rockstroh, Juergen Kurt and Spengler, Ulrich (2015). Survival and HLA-B*57 in HIV/HCV Co-Infected Patients on Highly Active Antiretroviral Therapy (HAART). PLoS One, 10 (8). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

Full text not available from this repository.

Abstract

Background and aims HLA class I alleles, in particular HLA-B*57, constitute the most consistent host factor determining outcomes in untreated HCV- and HIV-infection. In this prospective cohort study, we analysed the impact of HLA class I alleles on all-cause mortality in patients with HIV-, HCV-and HIV/HCV-co-infection receiving HAART. Methods In 2003 HLA-A and B alleles were determined and patients were prospectively followed in 3-month intervals until 2013 or death. HLA-A and B alleles were determined by strand-specific oligonucleotide hybridisation and PCR in 468 Caucasian patients with HCV-(n=120), HIV- (n=186) and HIV/HCV-infection (n=162). All patients with HIV-infection were on HAART. In each patient group, HLA class I-associated survival was analysed by Kaplan-Meier method and Cox regression analysis. Results At recruitment the proportion of patients carrying a HLA-B*57 allele differed between HIV-(12.9%) and HCV-infection (4.2%). Kaplan Meier analysis revealed significantly increased mortality in HLA-B*57-positive patients with HIV-infection (p=0.032) and HIV/HCV-co-infection (p=0.004), which was apparently linked to non-viral infections. Cox logistic regression analysis confirmed HLA-B*57 (p=0.001), serum gamma-glutamyltranspeptidase (p=0.003), serum bilirubin (p=0.022) and CD4 counts (p=0.041) as independent predictors of death in HIV-infected patients. Conclusion Differences in the prevalence of HLA-B*57 at study entry between HIV- and HCV-infected patients may reflect immune selection in the absence of antiviral therapy. When patients were treated with HAART, however, HLA-B*57 was associated with increased mortality and risk to die from bacterial infections and sepsis, suggesting an ambiguous role of HLAB*57 for survival in HIV/HCV infection depending on the circumstances.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Dold, Leona UNSPECIFIED UNSPECIFIED UNSPECIFIED Ahlenstiel, Golo UNSPECIFIED orcid.org/0000-0003-0026-1457 UNSPECIFIED Althausen, Eva UNSPECIFIED UNSPECIFIED UNSPECIFIED Luda, Carolin UNSPECIFIED UNSPECIFIED UNSPECIFIED Schwarze-Zander, Carolynne UNSPECIFIED UNSPECIFIED UNSPECIFIED Boesecke, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Wasmuth, Jan-Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Rockstroh, Juergen Kurt UNSPECIFIED UNSPECIFIED UNSPECIFIED Spengler, Ulrich UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-396629
DOI:	10.1371/journal.pone.0134158
Journal or Publication Title:	PLoS One
Volume:	10
Number:	8
Date:	2015
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ANTIGEN CLASS-I; HEPATITIS-C; REPLICATION CAPACITY; DISEASE PROGRESSION; VIRAL REPLICATION; HIV-INFECTION; INITIATION; ALLELES; GENOTYPE; OUTCOMES Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/39662