Universität zu Köln

Boeing, Sebastian and Randerath, Winfried J. (2015). Chronic hypoventilation syndromes and sleep-related hypoventilation. J. Thorac. Dis., 7 (8). S. 1273 - 1286. SHATIN: AME PUBL CO. ISSN 2077-6624

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Abstract

Chronic hypoventilation affects patients with disorders on any level of the respiratory system. The generation of respiratory impulses can be impaired in congenital disorders, such as central congenital alveolar hypoventilation, in alterations of the brain stem or complex diseases like obesity hypoventilation. The translation of the impulses via spinal cord and nerves to the respiratory muscles can be impaired in neurological diseases. Thoraco-skeletal or muscular diseases may inhibit the execution of the impulses. All hypoventilation disorders are characterized by a reduction of the minute ventilation with an increase of daytime hypercapnia. As sleep reduces minute ventilation substantially in healthy persons and much more pronounced in patients with underlying thoraco-pulmonary diseases, hypoventilation manifests firstly during sleep. Therefore, sleep related hypoventilation may be an early stage of chronic hypoventilation disorders. After treatment of any prevailing underlying disease, symptomatic therapy with non-invasive ventilation (NIV) is required. The adaptation of the treatment should be performed under close medical supervision. Pressure support algorithms have become most frequently used. The most recent devices automatically apply pressure support and vary inspiratory and expiratory pressures and breathing frequency in order to stabilize upper airways, normalize ventilation, achieve best synchronicity between patient and device and aim at optimizing patients' adherence.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Boeing, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Randerath, Winfried J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-397016
DOI:	10.3978/j.issn.2012-1439.2015.06.10
Journal or Publication Title:	J. Thorac. Dis.
Volume:	7
Number:	8
Page Range:	S. 1273 - 1286
Date:	2015
Publisher:	AME PUBL CO
Place of Publication:	SHATIN
ISSN:	2077-6624
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language OBSTRUCTIVE PULMONARY-DISEASE; CHRONIC RESPIRATORY-FAILURE; RANDOMIZED CROSSOVER TRIAL; INTENSITY NONINVASIVE VENTILATION; AMYOTROPHIC-LATERAL-SCLEROSIS; POSITIVE-PRESSURE VENTILATION; DUCHENNE MUSCULAR-DYSTROPHY; END-EXPIRATORY PRESSURE; OBESITY-HYPOVENTILATION; MECHANICAL VENTILATION Multiple languages Respiratory System Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/39701