Universität zu Köln

Bobylev, I., Elter, T., Schneider, C., Wunderlich, G., Zimmer, P., Streckmann, F., Fink, G. R. and Lehmann, H. C. (2015). Chemotherapy-induced Peripheral Neuropathy. Forschritte Neurol. Psychiatr., 83 (8). S. 427 - 437. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1439-3522

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Abstract

Chemotherapy-induced peripheral neuropathy (CIPN) is a common and relevant side effect of antineoplastic agents such as cisplatin, paclitaxel, vincristine and bortezomib. Over the last years, significant progress has been achieved in elucidating the underlying pathomechanisms of CIPN using both in vivo and in vitro models. These studies suggest that mitochondrial toxicity, disturbed axonal transport, toxic effects on Schwann cells and activation of the immune system contribute to the pathogenesis of CIPN. This review provides an overview of the current pathogenetic concepts of CIPN. In addition, experimental approaches that aim at preventing or ameliorating neurotoxic effects of antineoplastic agents are discussed.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bobylev, I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Elter, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schneider, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wunderlich, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zimmer, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Streckmann, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, G. R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lehmann, H. C. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-397237
DOI:	10.1055/s-0035-1553475
Journal or Publication Title:	Forschritte Neurol. Psychiatr.
Volume:	83
Number:	8
Page Range:	S. 427 - 437
Date:	2015
Publisher:	GEORG THIEME VERLAG KG
Place of Publication:	STUTTGART
ISSN:	1439-3522
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DORSAL-ROOT GANGLION; MARIE-TOOTH DISEASE; QUALITY-OF-LIFE; CISPLATIN-INDUCED APOPTOSIS; FAST AXONAL-TRANSPORT; MULTIPLE-MYELOMA; MITOCHONDRIAL DYSFUNCTION; DIFFERENTIAL EXPRESSION; VINCRISTINE NEUROPATHY; VASCULAR-PERMEABILITY Multiple languages Clinical Neurology; Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/39723