Universität zu Köln

Koksal, Muammer Osman, Beka, Hayati, Lubke, Nadine, Verheyen, Jens, Eraksoy, Haluk, Cagatay, Atahan, Kaiser, Rolf, Akgul, Baki ORCID: 0000-0002-6564-9412 and Agacfidan, Ali (2015). HIV-1 subtypes and drug resistance profiles in a cohort of heterosexual patients in Istanbul, Turkey. Med. Microbiol. Immunol., 204 (4). S. 551 - 556. NEW YORK: SPRINGER. ISSN 1432-1831

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Abstract

Turkey is seeing a steady rise in rates of HIV infection in the country. The number of individuals with HIV/AIDS was greater than 7000 in 2014 according to data released by the Ministry of Health, and heterosexual contacts were reported to be the main transmission routes. Istanbul has the highest number of reported cases of HIV infection. The aim of the study was to determine the prevalence of HIV-1 drug resistance in 50 heterosexual patients from Istanbul. The most prevalent subtype was found to be subtype B (56.2 %). Resistance-associated mutations were found in 14 patients with 6/14 patients being therapy-experienced and 8/14 therapy naive at the time point of analysis. With increasing number of patients who require treatment and the rapid up-scaling of the antiretroviral therapy in Turkey, HIV-1 drug resistance testing is recommended before starting treatment in order to achieve better clinical outcomes.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Koksal, Muammer Osman UNSPECIFIED UNSPECIFIED UNSPECIFIED Beka, Hayati UNSPECIFIED UNSPECIFIED UNSPECIFIED Lubke, Nadine UNSPECIFIED UNSPECIFIED UNSPECIFIED Verheyen, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Eraksoy, Haluk UNSPECIFIED UNSPECIFIED UNSPECIFIED Cagatay, Atahan UNSPECIFIED UNSPECIFIED UNSPECIFIED Kaiser, Rolf UNSPECIFIED UNSPECIFIED UNSPECIFIED Akgul, Baki UNSPECIFIED orcid.org/0000-0002-6564-9412 UNSPECIFIED Agacfidan, Ali UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-397651
DOI:	10.1007/s00430-015-0419-9
Journal or Publication Title:	Med. Microbiol. Immunol.
Volume:	204
Number:	4
Page Range:	S. 551 - 556
Date:	2015
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1432-1831
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language REVERSE-TRANSCRIPTASE; ANTIRETROVIRAL THERAPY; HIV-1-INFECTED PATIENTS; PROTEASE INHIBITORS; WILD-TYPE; MUTATIONS; SUSCEPTIBILITY; PATTERNS; NAIVE; GENE Multiple languages Immunology; Microbiology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/39765