Universität zu Köln

Saville, Christopher W. N., Lancaster, Thomas M., Davies, Timothy J., Toumaian, Maida, Pappa, Eleni, Fish, Simon, Feige, Bernd ORCID: 0000-0002-9436-1258, Bender, Stephan, Mantripragada, Kiran K., Linden, David E. J. and Klein, Christoph (2015). Elevated P3b latency variability in carriers of ZNF804A risk allele for psychosis. Neuroimage, 116. S. 207 - 214. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE. ISSN 1095-9572

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Abstract

Increased intra-subject variability (ISV) in reaction times (RTs) is a candidate endophenotype for several psychiatric and neurological conditions, including schizophrenia. ISV reflects the degree of variability in RTs and is thought to be an index of the stability of cognition. It is generally assumed to have the same underlying physiological basis across conditions, but recent evidence raises the possibility that the neural underpinnings of ISV vary with aetiology. Combining genetics with single-trial event-related potentials is an ideal method for investigating the neural basis of ISV in groups where ISV may vary for relatively homogenous reasons. Here we examine the association between P3b latency variability and a polymorphismon the ZNF804A gene associated with psychosis. Ninety-one healthy volunteers genotyped for rs1344706, a polymorphism on ZNF804A, had electroencephalographic data recorded while carrying out three n-back tasks. Data were analysed with a single-trial approach and latency variability of the P3b was compared between the AA homozygous risk group (N = 30) and C allele carriers (N = 61). P3b latencies were more variable for AA carriers than C carriers. Behavioural ISV, however, was not associated with genotype. The increase in neurophysiological variability, unaccompanied by increased behavioural variability, suggests that this risk gene is associated with an attenuated form of an endophenotype associated with the psychosis phenotype. The increase in both stimulus and response-locked variability also contrasts with previous work into attention deficit hyperactivity disorder, where only response-locked P3b variability was elevated, suggesting that increased ISV may not signify the same underlying processes in all conditions with which it is associated. (C) 2015 Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Saville, Christopher W. N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lancaster, Thomas M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Davies, Timothy J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Toumaian, Maida UNSPECIFIED UNSPECIFIED UNSPECIFIED Pappa, Eleni UNSPECIFIED UNSPECIFIED UNSPECIFIED Fish, Simon UNSPECIFIED UNSPECIFIED UNSPECIFIED Feige, Bernd UNSPECIFIED orcid.org/0000-0002-9436-1258 UNSPECIFIED Bender, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED Mantripragada, Kiran K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Linden, David E. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Klein, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-398562
DOI:	10.1016/j.neuroimage.2015.04.024
Journal or Publication Title:	Neuroimage
Volume:	116
Page Range:	S. 207 - 214
Date:	2015
Publisher:	ACADEMIC PRESS INC ELSEVIER SCIENCE
Place of Publication:	SAN DIEGO
ISSN:	1095-9572
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; REACTION-TIME VARIABILITY; WHITE-MATTER INTEGRITY; INTRAINDIVIDUAL VARIABILITY; WORKING-MEMORY; PARKINSONS-DISEASE; SCHIZOPHRENIA; PERFORMANCE; VARIANT; GENE Multiple languages Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/39856