Universität zu Köln

Crameri, Aureliano, von Wyl, Agnes, Koemeda, Margit, Schulthess, Peter and Tschuschke, Volker (2015). Sensitivity analysis in multiple imputation in effectiveness studies of psychotherapy. Front. Psychol., 6. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1664-1078

Full text not available from this repository.

Abstract

The importance of preventing and treating incomplete data in effectiveness studies is nowadays emphasized. However, most of the publications focus on randomized clinical trials (RCT). One flexible technique for statistical inference with missing data is multiple imputation (MI). Since methods such as MI rely on the assumption of missing data being at random (MAR), a sensitivity analysis for testing the robustness against departures from this assumption is required. In this paper we present a sensitivity analysis technique based on posterior predictive checking, which takes into consideration the concept of clinical significance used in the evaluation of intra-individual changes. We demonstrate the possibilities this technique can offer with the example of irregular longitudinal data collected with the Outcome Questionnaire-45 (OQ-45) and the Helping Alliance Questionnaire (HAQ) in a sample of 260 outpatients. The sensitivity analysis can be used to (1) quantify the degree of bias introduced by missing not at random data (MNAR) in a worst reasonable case scenario, (2) compare the performance of different analysis methods for dealing with missing data, or (3) detect the influence of possible violations to the model assumptions (e.g., lack of normality). Moreover, our analysis showed that ratings from the patient's and therapist's version of the HAQ could significantly improve the predictive value of the routine outcome monitoring based on the OQ-45. Since analysis dropouts always occur, repeated measurements with the OQ-45 and the HAQ analyzed with MI are useful to improve the accuracy of outcome estimates in quality assurance assessments and non-randomized effectiveness studies in the field of outpatient psychotherapy.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Crameri, Aureliano UNSPECIFIED UNSPECIFIED UNSPECIFIED von Wyl, Agnes UNSPECIFIED UNSPECIFIED UNSPECIFIED Koemeda, Margit UNSPECIFIED UNSPECIFIED UNSPECIFIED Schulthess, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Tschuschke, Volker UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-398636
DOI:	10.3389/fpsyg.2015.01042
Journal or Publication Title:	Front. Psychol.
Volume:	6
Date:	2015
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	1664-1078
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language THERAPEUTIC ALLIANCE; MISSING DATA; LONGITUDINAL DATA; FOLLOW-UP; SIMULATION; CLIENTS; TESTS Multiple languages Psychology, Multidisciplinary Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/39863