Universität zu Köln

Peiker, Ina, Schneider, Till R., Milne, Elizabeth, Schoettle, Daniel, Vogeley, Kai, Muenchau, Alexander, Schunke, Odette, Siegel, Markus ORCID: 0000-0001-5115-936X, Engel, Andreas K. ORCID: 0000-0003-4899-8466 and David, Nicole (2015). Stronger Neural Modulation by Visual Motion Intensity in Autism Spectrum Disorders. PLoS One, 10 (7). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

Theories of autism spectrum disorders (ASD) have focused on altered perceptual integration of sensory features as a possible core deficit. Yet, there is little understanding of the neuronal processing of elementary sensory features in ASD. For typically developed individuals, we previously established a direct link between frequency-specific neural activity and the intensity of a specific sensory feature: Gamma-band activity in the visual cortex increased approximately linearly with the strength of visual motion. Using magnetoencephalography (MEG), we investigated whether in individuals with ASD neural activity reflect the coherence, and thus intensity, of visual motion in a similar fashion. Thirteen adult participants with ASD and 14 control participants performed a motion direction discrimination task with increasing levels of motion coherence. A polynomial regression analysis revealed that gamma-band power increased significantly stronger with motion coherence in ASD compared to controls, suggesting excessive visual activation with increasing stimulus intensity originating from motion-responsive visual areas V3, V6 and hMT/V5. Enhanced neural responses with increasing stimulus intensity suggest an enhanced response gain in ASD. Response gain is controlled by excitatory-inhibitory interactions, which also drive high-frequency oscillations in the gamma-band. Thus, our data suggest that a disturbed excitatory-inhibitory balance underlies enhanced neural responses to coherent motion in ASD.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Peiker, Ina UNSPECIFIED UNSPECIFIED UNSPECIFIED Schneider, Till R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Milne, Elizabeth UNSPECIFIED UNSPECIFIED UNSPECIFIED Schoettle, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Vogeley, Kai UNSPECIFIED UNSPECIFIED UNSPECIFIED Muenchau, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Schunke, Odette UNSPECIFIED UNSPECIFIED UNSPECIFIED Siegel, Markus UNSPECIFIED orcid.org/0000-0001-5115-936X UNSPECIFIED Engel, Andreas K. UNSPECIFIED orcid.org/0000-0003-4899-8466 UNSPECIFIED David, Nicole UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-398967
DOI:	10.1371/journal.pone.0132531
Journal or Publication Title:	PLoS One
Volume:	10
Number:	7
Date:	2015
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GAMMA-BAND ACTIVITY; ASPERGER-SYNDROME; ILLUSORY FIGURES; RECEPTIVE-FIELD; TOP-DOWN; AREA MT; SYNCHRONIZATION; OSCILLATIONS; PERCEPTION; FREQUENCY Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/39896