Universität zu Köln

Lindner, Sven, Bachmann, Hagen S., Odersky, Andrea, Schaefers, Simon, Klein-Hitpass, Ludger, Hero, Barbara, Fischer, Matthias, Eggert, Angelika ORCID: 0000-0003-3476-8184, Schramm, Alexander ORCID: 0000-0001-7670-7529 and Schulte, Johannes H. (2015). Absence of telomerase reverse transcriptase promoter mutations in neuroblastoma. Biomed. Rep., 3 (4). S. 443 - 447. ATHENS: SPANDIDOS PUBL LTD. ISSN 2049-9442

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Abstract

Maintenance of telomere length is a critical hallmark of malignant transformation. While silenced in somatic cells, telomerase reverse transcriptase (TERT), the catalytic subunit of telomerase, is frequently overexpressed in malignant cells thereby maintaining their telomere length. Specific point mutations in the TERT promoter region have recently been identified in melanoma and other tumor entities resulting in high TERT expression. Neuroblastoma is the most common extracranial tumor of childhood, arising from neural-crest progenitor cells. TERT overexpression has been observed in the majority of neuroblastoma. Taking into consideration that TERT promoter mutations are frequently described in neural-crest-derived tumors such as melanoma, as well as a variety of other neuronal tumors, the present study analyzed the frequency of TERT promoter mutations in primary neuroblastoma and neuroblastoma cell lines. In 131 neuroblastoma primary tumors representing the whole spectrum of neuroblastoma, no TERT promoter mutations were detected. However, in 3 out of 19 neuroblastoma cell lines the previously described C228T TERT promoter mutation was present. In conclusion, the TERT promoter mutations are not a frequent mechanism of TERT overexpression in neuroblastoma.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lindner, Sven UNSPECIFIED UNSPECIFIED UNSPECIFIED Bachmann, Hagen S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Odersky, Andrea UNSPECIFIED UNSPECIFIED UNSPECIFIED Schaefers, Simon UNSPECIFIED UNSPECIFIED UNSPECIFIED Klein-Hitpass, Ludger UNSPECIFIED UNSPECIFIED UNSPECIFIED Hero, Barbara UNSPECIFIED UNSPECIFIED UNSPECIFIED Fischer, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Eggert, Angelika UNSPECIFIED orcid.org/0000-0003-3476-8184 UNSPECIFIED Schramm, Alexander UNSPECIFIED orcid.org/0000-0001-7670-7529 UNSPECIFIED Schulte, Johannes H. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-399169
DOI:	10.3892/br.2015.463
Journal or Publication Title:	Biomed. Rep.
Volume:	3
Number:	4
Page Range:	S. 443 - 447
Date:	2015
Publisher:	SPANDIDOS PUBL LTD
Place of Publication:	ATHENS
ISSN:	2049-9442
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HIGHLY RECURRENT; GENE-EXPRESSION; TUMORS; MELANOMA; CELLS; MYC; MEDULLOBLASTOMA; CANCER Multiple languages Medicine, Research & Experimental Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/39916