Universität zu Köln

Miliara, Xeni, Garnett, James A., Tatsuta, Takashi, Abid Ali, Ferdos ORCID: 0000-0002-2903-3194, Baldie, Heather, Perez-Dorado, Inmaculada, Simpson, Peter, Yague, Ernesto, Langer, Thomas ORCID: 0000-0003-1250-1462 and Matthews, Stephen (2015). Structural insight into the TRIAP1/PRELI-like domain family of mitochondrial phospholipid transfer complexes. EMBO Rep., 16 (7). S. 824 - 836. HOBOKEN: WILEY. ISSN 1469-3178

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Abstract

The composition of the mitochondrial membrane is important for its architecture and proper function. Mitochondria depend on a tightly regulated supply of phospholipid via intra-mitochondrial synthesis and by direct import from the endoplasmic reticulum. The Ups1/PRELI-like family together with its mitochondrial chaperones (TRIAP1/Mdm35) represent a unique heterodimeric lipid transfer system that is evolutionary conserved from yeast to man. Work presented here provides new atomic resolution insight into the function of a human member of this system. Crystal structures of free TRIAP1 and the TRIAP1-SLMO1 complex reveal how the PRELI domain is chaperoned during import into the intermembrane mitochondrial space. The structural resemblance of PRELI-like domain of SLMO1 with that of mammalian phoshatidylinositol transfer proteins (PITPs) suggest that they share similar lipid transfer mechanisms, in which access to a buried phospholipid-binding cavity is regulated by conformationally adaptable loops.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Miliara, Xeni UNSPECIFIED UNSPECIFIED UNSPECIFIED Garnett, James A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Tatsuta, Takashi UNSPECIFIED UNSPECIFIED UNSPECIFIED Abid Ali, Ferdos UNSPECIFIED orcid.org/0000-0002-2903-3194 UNSPECIFIED Baldie, Heather UNSPECIFIED UNSPECIFIED UNSPECIFIED Perez-Dorado, Inmaculada UNSPECIFIED UNSPECIFIED UNSPECIFIED Simpson, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Yague, Ernesto UNSPECIFIED UNSPECIFIED UNSPECIFIED Langer, Thomas UNSPECIFIED orcid.org/0000-0003-1250-1462 UNSPECIFIED Matthews, Stephen UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-400275
DOI:	10.15252/embr.201540229
Journal or Publication Title:	EMBO Rep.
Volume:	16
Number:	7
Page Range:	S. 824 - 836
Date:	2015
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1469-3178
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INTERMEMBRANE SPACE PROTEINS; INTRAMITOCHONDRIAL TRANSPORT; PHOSPHATIDIC-ACID; CARDIOLIPIN; UPS1P; IMPORT Multiple languages Biochemistry & Molecular Biology; Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/40027