Universität zu Köln

Kohl, S., Aggeli, K., Obeso, I., Speekenbrink, M., Limousin, P., Kuhn, J. and Jahanshahi, M. (2015). In Parkinson's disease pallidal deep brain stimulation speeds up response initiation but has no effect on reactive inhibition. J. Neurol., 262 (7). S. 1741 - 1751. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1432-1459

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Abstract

The fronto-striatal circuits are considered to mediate inhibitory control over action. The aim of this study was to investigate the contribution of the internal segment of the pallidum (GPi), one of the final output pathways from the basal ganglia to the cortex, in inhibition. We examined the effect of deep brain stimulation (DBS) of the GPi (GPi-DBS) in patients with Parkinson's disease who performed a conditional stop signal task, with DBS on and off. Modulation of GPi activity was associated with significantly faster Go reaction times with DBS on than off, but stop signal reaction times were not altered. Application of the drift diffusion model indicated that GPi-DBS was associated with significantly lower response thresholds compared to GPi-DBS off. However, the drift rate was significantly lower than healthy controls with both GPi-DBS on and off. These results suggest that the GPi plays a crucial role in the 'Go' pathway, perhaps facilitating reaching the required threshold to initiate actions. However, GPi-DBS does not alter the functioning of the indirect 'NoGo' pathway, and other basal ganglia nuclei, such as the STN, may play a greater role in reactive response inhibition and conflict resolution.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kohl, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Aggeli, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Obeso, I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Speekenbrink, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Limousin, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kuhn, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jahanshahi, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-400428
DOI:	10.1007/s00415-015-7768-6
Journal or Publication Title:	J. Neurol.
Volume:	262
Number:	7
Page Range:	S. 1741 - 1751
Date:	2015
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1432-1459
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language STOP-SIGNAL TASK; HUMAN SUBTHALAMIC NUCLEUS; BASAL GANGLIA; MODEL; MULTICENTER; SELECTION; CONFLICT; PATHWAYS Multiple languages Clinical Neurology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/40042