Erny, Daniel ORCID: 0000-0001-6000-8838, de Angelis, Anna Lena Hrabe, Jaitin, Diego, Wieghofer, Peter, Staszewski, Ori ORCID: 0000-0002-0579-6701, David, Eyal, Keren-Shaul, Hadas, Mahlakoiv, Tanel ORCID: 0000-0001-9059-0486, Jakobshagen, Kristin, Buch, Thorsten ORCID: 0000-0002-2236-9074, Schwierzeck, Vera ORCID: 0000-0003-4254-3700, Utermoehlen, Olaf, Chun, Eunyoung, Garrett, Wendy S., Mccoy, Kathy D., Diefenbach, Andreas ORCID: 0000-0002-9176-9530, Staeheli, Peter, Stecher, Baerbel, Amit, Ido and Prinz, Marco (2015). Host microbiota constantly control maturation and function of microglia in the CNS. Nat. Neurosci., 18 (7). S. 965 - 980. NEW YORK: NATURE PUBLISHING GROUP. ISSN 1546-1726

Full text not available from this repository.

Abstract

As the tissue macrophages of the CNS, microglia are critically involved in diseases of the CNS. However, it remains unknown what controls their maturation and activation under homeostatic conditions. We observed substantial contributions of the host microbiota to microglia homeostasis, as germ-free (GF) mice displayed global defects in microglia with altered cell proportions and an immature phenotype, leading to impaired innate immune responses. Temporal eradication of host microbiota severely changed microglia properties. Limited microbiota complexity also resulted in defective microglia. In contrast, recolonization with a complex microbiota partially restored microglia features. We determined that short-chain fatty acids (SCFA), microbiota-derived bacterial fermentation products, regulated microglia homeostasis. Accordingly, mice deficient for the SCFA receptor FFAR2 mirrored microglia defects found under GF conditions. These findings suggest that host bacteria vitally regulate microglia maturation and function, whereas microglia impairment can be rectified to some extent by complex microbiota.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Erny, DanielUNSPECIFIEDorcid.org/0000-0001-6000-8838UNSPECIFIED
de Angelis, Anna Lena HrabeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jaitin, DiegoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wieghofer, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Staszewski, OriUNSPECIFIEDorcid.org/0000-0002-0579-6701UNSPECIFIED
David, EyalUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Keren-Shaul, HadasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mahlakoiv, TanelUNSPECIFIEDorcid.org/0000-0001-9059-0486UNSPECIFIED
Jakobshagen, KristinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buch, ThorstenUNSPECIFIEDorcid.org/0000-0002-2236-9074UNSPECIFIED
Schwierzeck, VeraUNSPECIFIEDorcid.org/0000-0003-4254-3700UNSPECIFIED
Utermoehlen, OlafUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chun, EunyoungUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Garrett, Wendy S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mccoy, Kathy D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Diefenbach, AndreasUNSPECIFIEDorcid.org/0000-0002-9176-9530UNSPECIFIED
Staeheli, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stecher, BaerbelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Amit, IdoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Prinz, MarcoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-400546
DOI: 10.1038/nn.4030
Journal or Publication Title: Nat. Neurosci.
Volume: 18
Number: 7
Page Range: S. 965 - 980
Date: 2015
Publisher: NATURE PUBLISHING GROUP
Place of Publication: NEW YORK
ISSN: 1546-1726
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
GUT MICROBIOTA; COMMON VARIANTS; CELLS; ACTIVATION; HEMATOPOIESIS; MACROPHAGES; METABOLITES; PHYSIOLOGY; EXPRESSION; MONOCYTESMultiple languages
NeurosciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/40054

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item