Universität zu Köln

Ganse, Bergita ORCID: 0000-0002-9512-2910, Zange, Jochen, Weber, Tobias, Pohle-Froehlich, Regina, Johannes, Bernd W., Hackenbroch, Matthias, Ritweger, Joern, Eysel, Peer and Koy, Timmo (2015). Muscular forces affect the glycosaminoglycan content of joint cartilage. Acta Orthop., 86 (3). S. 388 - 393. NEW YORK: INFORMA HEALTHCARE. ISSN 1745-3682

Full text not available from this repository.

Abstract

Background and purpose - Unloading alters the thickness of joint cartilage. It is unknown, however, to what extent unloading leads to a loss of glycosaminoglycans (GAGs) in the cartilage tissue. We hypothesized that muscle forces, in addition to axial loading, are necessary to maintain the joint cartilage GAG content of the knee and the upper and lower ankle. Patients and methods - The HEPHAISTOS orthosis was worn unilaterally by 11 men (mean age 31 (23-50) years old) for 56 days. The orthosis reduces activation and force production of the calf muscles while it permits full gravitational loading of the lower leg. MRI measurements of the knee and ankle were taken before the intervention, during the intervention (on day 49), and 14 days after the end of the intervention. Cartilage segmentation was conducted semiautomatically for the knee joint (4 segments) and for the upper (tibio-talar) and lower (subtalar) ankle joints (2 segments each). Linear mixed-effects (LME) models were used for statistical analysis. Results - 8 volunteers completed the MRI experiment. In the lower ankle joint, differences in Delta T-1 were found between the end of the intervention and 14 days after (p = 0.004), indicating a decrease in GAG content after reloading. There were no statistically significant differences in Delta T-1 values in the knee and upper ankle joints. Interpretation - Our findings suggest that in addition to gravitational load, muscular forces affect cartilage composition depending on the local distribution of forces in the joints affected by muscle contraction.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ganse, Bergita UNSPECIFIED orcid.org/0000-0002-9512-2910 UNSPECIFIED Zange, Jochen UNSPECIFIED UNSPECIFIED UNSPECIFIED Weber, Tobias UNSPECIFIED UNSPECIFIED UNSPECIFIED Pohle-Froehlich, Regina UNSPECIFIED UNSPECIFIED UNSPECIFIED Johannes, Bernd W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hackenbroch, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Ritweger, Joern UNSPECIFIED UNSPECIFIED UNSPECIFIED Eysel, Peer UNSPECIFIED UNSPECIFIED UNSPECIFIED Koy, Timmo UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-402606
DOI:	10.3109/17453674.2014.989382
Journal or Publication Title:	Acta Orthop.
Volume:	86
Number:	3
Page Range:	S. 388 - 393
Date:	2015
Publisher:	INFORMA HEALTHCARE
Place of Publication:	NEW YORK
ISSN:	1745-3682
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GADOLINIUM-ENHANCED MRI; ARTICULAR-CARTILAGE; KNEE CARTILAGE; EXERCISE; ANKLE Multiple languages Orthopedics Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/40260