Universität zu Köln

Hengevoss, Jonas, Piechotta, Marion, Mueller, Dennis, Hanft, Fabian, Parr, Maria Kristina ORCID: 0000-0001-7407-8300, Schaenzer, Wilhelm and Diel, Patrick (2015). Combined effects of androgen anabolic steroids and physical activity on the hypothalamic-pituitary-gonadal axis. J. Steroid Biochem. Mol. Biol., 150. S. 86 - 97. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD. ISSN 0960-0760

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Abstract

Analysing effects of pharmaceutical substances and training on feedback mechanisms of the hypothalamic-pituitary-gonadal axis may be helpful to quantify the benefit of strategies preventing loss of muscle mass, and in the fight against doping. In this study we analysed combined effects of anabolic steroids and training on the hypothalamic-pituitary-gonadal axis. Therefore intact male Wistar rats were dose-dependently treated with metandienone, estradienedione and the selective androgen receptor modulator (SARM) S-1. In serum cortisol, testosterone, 17 beta-estradiol (E2), prolactin, inhibin B, follicle-stimulating hormone (FSH), luteinizing hormone (LH), Insulin-like growth factor 1 (IGF-1), and thyroxine (T4) concentrations were determined. Six human volunteers were single treated with 1-androstenedione. In addition abusing and clean body builders were analysed. Serum concentrations of inhibin B, IGF-1, cortisol, prolactin, T4, thyroid-stimulating hormone (TSH), testosterone and LH were determined. In rats, administration of metandienone, estradienedione and S-1 resulted in an increase of muscle fiber diameter. Metandienone and estradienedione but not S-1 administration significantly decreases LH and inhibin B serum concentration. Administration of estradienedione resulted in an increase of E2 and S-1 in an increase of cortisol. Single administration of 1-androstenedione in humans decreased cortisol and inhibin B serum concentrations. LH was not affected. In abusing body builders a significantly decrease of LH, TSH and inhibin B and an increase of prolactin, IGF-1 and T4 was detected. In clean body builders only T4 and TSH were affected. (C) 2015 Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hengevoss, Jonas UNSPECIFIED UNSPECIFIED UNSPECIFIED Piechotta, Marion UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Dennis UNSPECIFIED UNSPECIFIED UNSPECIFIED Hanft, Fabian UNSPECIFIED UNSPECIFIED UNSPECIFIED Parr, Maria Kristina UNSPECIFIED orcid.org/0000-0001-7407-8300 UNSPECIFIED Schaenzer, Wilhelm UNSPECIFIED UNSPECIFIED UNSPECIFIED Diel, Patrick UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-402930
DOI:	10.1016/j.jsbmb.2015.03.003
Journal or Publication Title:	J. Steroid Biochem. Mol. Biol.
Volume:	150
Page Range:	S. 86 - 97
Date:	2015
Publisher:	PERGAMON-ELSEVIER SCIENCE LTD
Place of Publication:	OXFORD
ISSN:	0960-0760
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SKELETAL-MUSCLE; RECEPTOR MODULATOR; THYROID-HORMONES; EXERCISE; TESTOSTERONE; LEPTIN; CELLS; SUPPRESSES; PHYSIOLOGY; PROLACTIN Multiple languages Biochemistry & Molecular Biology; Endocrinology & Metabolism Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/40293