Universität zu Köln

Papastefanaki, Florentia, Jakovcevski, Igor ORCID: 0000-0001-7673-9600, Poulia, Nafsika, Djogo, Nevena, Schulz, Florian ORCID: 0000-0003-4440-3680, Martinovic, Tamara ORCID: 0000-0001-5346-6398, Ciric, Darko ORCID: 0000-0003-2791-8690, Loers, Gabrielle, Vossmeyer, Tobias, Weller, Horst, Schachner, Melitta and Matsas, Rebecca (2015). Intraspinal Delivery of Polyethylene Glycol-coated Gold Nanoparticles Promotes Functional Recovery After Spinal Cord Injury. Mol. Ther., 23 (6). S. 993 - 1003. NEW YORK: NATURE PUBLISHING GROUP. ISSN 1525-0024

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Abstract

Failure of the mammalian central nervous system (CNS) to regenerate effectively after injury leads to mostly irreversible functional impairment. Gold nanoparticles (AuNPs) are promising candidates for drug delivery in combination with tissue-compatible reagents, such as polyethylene glycol (PEG). PEG administration in CNS injury models has received interest for potential therapy, but toxicity and low bioavailability prevents clinical application. Here we show that intraspinal delivery of PEG-functionalized 40-nm-AuNPs at early stages after mouse spinal cord injury is beneficial for recovery. Positive outcome of hind limb motor function was accompanied by attenuated inflammatory response, enhanced motor neuron survival, and increased myelination of spared or regrown/sprouted axons. No adverse effects, such as body weight loss, ill health, or increased mortality were observed. We propose that PEG-AuNPs represent a favorable drug-delivery platform with therapeutic potential that could be further enhanced if PEG-AuNPs are used as carriers of regeneration-promoting molecules.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Papastefanaki, Florentia UNSPECIFIED UNSPECIFIED UNSPECIFIED Jakovcevski, Igor UNSPECIFIED orcid.org/0000-0001-7673-9600 UNSPECIFIED Poulia, Nafsika UNSPECIFIED UNSPECIFIED UNSPECIFIED Djogo, Nevena UNSPECIFIED UNSPECIFIED UNSPECIFIED Schulz, Florian UNSPECIFIED orcid.org/0000-0003-4440-3680 UNSPECIFIED Martinovic, Tamara UNSPECIFIED orcid.org/0000-0001-5346-6398 UNSPECIFIED Ciric, Darko UNSPECIFIED orcid.org/0000-0003-2791-8690 UNSPECIFIED Loers, Gabrielle UNSPECIFIED UNSPECIFIED UNSPECIFIED Vossmeyer, Tobias UNSPECIFIED UNSPECIFIED UNSPECIFIED Weller, Horst UNSPECIFIED UNSPECIFIED UNSPECIFIED Schachner, Melitta UNSPECIFIED UNSPECIFIED UNSPECIFIED Matsas, Rebecca UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-402944
DOI:	10.1038/mt.2015.50
Journal or Publication Title:	Mol. Ther.
Volume:	23
Number:	6
Page Range:	S. 993 - 1003
Date:	2015
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	NEW YORK
ISSN:	1525-0024
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CENTRAL-NERVOUS-SYSTEM; OXIDATIVE STRESS; SCHWANN-CELLS; IN-VIVO; REPAIR; REGENERATION; CONDUCTION; INHIBITION; NEUROTOXICITY; REMYELINATION Multiple languages Biotechnology & Applied Microbiology; Genetics & Heredity; Medicine, Research & Experimental Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/40294