Universität zu Köln

Zeriouh, Mohamed, Mohite, Prashant N., Sabashnikov, Anton ORCID: 0000-0002-6289-1035, Zych, Bartlomiej, Patil, Nikhil P., Garcia-Saez, Diana, Koch, Achim, Ghodsizad, Ali, Weymann, Alexander, Soresi, Simona, Wittwer, Thorsten, Choi, Yeong-Hoon, Wippermann, Jens, Wahlers, Thorsten, Popov, Aron-Frederik ORCID: 0000-0003-4226-3004 and Simon, Andre R. (2015). Lung transplantation in chronic obstructive pulmonary disease: long-term survival, freedom from bronchiolitis obliterans syndrome, and factors influencing outcome. Clin. Transplant., 29 (4). S. 383 - 393. HOBOKEN: WILEY. ISSN 1399-0012

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Abstract

ObjectivesLung transplantation (LTx) remains the definitive treatment for end-stage lung failure, whereas chronic obstructive pulmonary disease (COPD) represents one of the main diagnoses leading to the indication for a transplant. We sought to assess long-term outcomes after LTx in patients diagnosed with COPD and analyze factors influencing outcome in this frequent patient cohort. MethodsBetween January 2007 and November 2013, a total of 88 LTx were performed in patients with COPD in our institution. Patients with emphysema associated with alpha1-antitrypsin deficiency were excluded from this observation. The study design was a retrospective review of the prospectively collected data. A large number of pre-, intra-, and postoperative variables were analyzed including long-term survival and freedom from bronchiolitis obliterans syndrome (BOS). Furthermore, impact of different variables on survival was analyzed. ResultsPreoperative donor data indicated a large proportion of marginal donors. While the overall cumulative survival after six yr was 57.4%, the results in terms of BOS-free survival in long-term follow-up were 39.7% after six yr. Patients with COPD were also associated with a low incidence (2.3%) of the need for postoperative extracorporeal life support (ECLS). ConclusionsLong-term results after LTx in patients with COPD are acceptable with excellent survival, freedom from BOS, and low use of ECLS postoperatively despite permanently increasing proportion of marginal organs used.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Zeriouh, Mohamed UNSPECIFIED UNSPECIFIED UNSPECIFIED Mohite, Prashant N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sabashnikov, Anton UNSPECIFIED orcid.org/0000-0002-6289-1035 UNSPECIFIED Zych, Bartlomiej UNSPECIFIED UNSPECIFIED UNSPECIFIED Patil, Nikhil P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Garcia-Saez, Diana UNSPECIFIED UNSPECIFIED UNSPECIFIED Koch, Achim UNSPECIFIED UNSPECIFIED UNSPECIFIED Ghodsizad, Ali UNSPECIFIED UNSPECIFIED UNSPECIFIED Weymann, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Soresi, Simona UNSPECIFIED UNSPECIFIED UNSPECIFIED Wittwer, Thorsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Choi, Yeong-Hoon UNSPECIFIED UNSPECIFIED UNSPECIFIED Wippermann, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Wahlers, Thorsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Popov, Aron-Frederik UNSPECIFIED orcid.org/0000-0003-4226-3004 UNSPECIFIED Simon, Andre R. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-403127
DOI:	10.1111/ctr.12528
Journal or Publication Title:	Clin. Transplant.
Volume:	29
Number:	4
Page Range:	S. 383 - 393
Date:	2015
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1399-0012
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PRIMARY GRAFT DYSFUNCTION; CLINICAL RISK-FACTORS; INTERNATIONAL-SOCIETY; ADULT LUNG; EMPHYSEMA; HEART; DONOR; COPD; MANAGEMENT; REGISTRY Multiple languages Surgery; Transplantation Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/40312