Universität zu Köln

Denzel, Martin S. and Antebi, Adam (2015). Hexosamine pathway and (ER) protein quality control. Curr. Opin. Cell Biol., 33. S. 14 - 19. LONDON: CURRENT BIOLOGY LTD. ISSN 1879-0410

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Abstract

Aminosugars produced in the hexosamine pathway (HP) are utilized in protein glycosylation reactions involved in protein maturation and cellular signaling. Recent evidence revealed a role of the HP in protein quality control and ageing. Elevation of the HP product UDP-N-acetylglucosamine in the nematode Caenorhabditis elegans results in resistance towards toxic aggregation-prone proteins, and extended lifespan. Glutamine-fructose 6 phosphate aminotransferase (GFAT-1), the HP's key enzyme, is a target of the unfolded protein response (UPR). Thus, cardiac stress in mice results in GFAT-1 activation that triggers a cytoprotective response. Feeding of glucosamine to aged mice increases their life expectancy. Here we discuss HP activation and cellular protein quality control mechanisms that result in stress resistance and suppression of age-related proteotoxicity.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Denzel, Martin S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Antebi, Adam UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-404002
DOI:	10.1016/j.ceb.2014.10.001
Journal or Publication Title:	Curr. Opin. Cell Biol.
Volume:	33
Page Range:	S. 14 - 19
Date:	2015
Publisher:	CURRENT BIOLOGY LTD
Place of Publication:	LONDON
ISSN:	1879-0410
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language EXTENDS LIFE-SPAN; O-GLCNACYLATION; CHEMICAL CHAPERONES; MOUSE MODEL; ACTIVATION; PHOSPHORYLATION; GLYCOSYLATION; BIOSYNTHESIS; STRESS; SITE Multiple languages Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/40400