Universität zu Köln

Polidori, M. C., Ruggiero, C., Croce, M. F., Raichi, T., Mangialasche, F., Cecchetti, R., Pelini, L., Paolacci, L., Ercolani, S. and Mecocci, P. (2015). Association of increased carotid intima-media thickness and lower plasma levels of vitamin C and vitamin E in old age subjects: implications for Alzheimer's disease. J. Neural Transm., 122 (4). S. 523 - 531. WIEN: SPRINGER WIEN. ISSN 1435-1463

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Abstract

In light of the recent advances regarding the role of vascularity in Alzheimer's disease (AD) pathophysiology, the relationship between plasma levels and activities of the major antioxidant molecules and the carotid intima-media thickness (C-IMT) of older persons with no or very mild cognitive impairment was evaluated. The underlying hypothesis is that the IMT may be an indirect index of vascular damage in persons with low levels of plasma antioxidants. Plasma levels of vitamins A, C, E, of uric acid as well as activities of the plasma antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GPx) were measured. Plasma levels of vitamins C and E significantly decreased among participants from the first to the fourth IMT quartile, with a linear slope only for vitamin C. Compared to participants in the lowest vitamin C quartile, the probability to have IMT > 1.2 mm significantly decreased among persons from the second to the fourth quartile independent of confounders. In conclusion, only vitamin C plasma levels appear to be selectively associated with the risk of increasing C-IMT. An adequate vitamin C status might be particularly important for protection against AD and other clinical manifestations of vascular and cognitive ageing.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Polidori, M. C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruggiero, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Croce, M. F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Raichi, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mangialasche, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cecchetti, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pelini, L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Paolacci, L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ercolani, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mecocci, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-404238
DOI:	10.1007/s00702-014-1357-1
Journal or Publication Title:	J. Neural Transm.
Volume:	122
Number:	4
Page Range:	S. 523 - 531
Date:	2015
Publisher:	SPRINGER WIEN
Place of Publication:	WIEN
ISSN:	1435-1463
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CORONARY-HEART-DISEASE; ASCORBIC-ACID; RISK-FACTORS; ANTIOXIDANT STATUS; COGNITIVE DECLINE; EUROPEAN-SOCIETY; TASK-FORCE; DEMENTIA; ATHEROSCLEROSIS; MORTALITY Multiple languages Clinical Neurology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/40423