Universität zu Köln

Redkar, Amey ORCID: 0000-0001-5171-8061, Hoser, Rafal, Schilling, Lena, Zechmann, Bernd ORCID: 0000-0002-7702-2588, Krzymowska, Magdalena ORCID: 0000-0001-9016-9165, Walbot, Virginia and Doehlemann, Gunther ORCID: 0000-0002-7353-8456 (2015). A Secreted Effector Protein of Ustilago maydis Guides Maize Leaf Cells to Form Tumors. Plant Cell, 27 (4). S. 1332 - 1352. ROCKVILLE: AMER SOC PLANT BIOLOGISTS. ISSN 1532-298X

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Abstract

The biotrophic smut fungus Ustilago maydis infects all aerial organs of maize (Zea mays) and induces tumors in the plant tissues. U. maydis deploys many effector proteins to manipulate its host. Previously, deletion analysis demonstrated that several effectors have important functions in inducing tumor expansion specifically in maize leaves. Here, we present the functional characterization of the effector See1 (Seedling efficient effector1). See1 is required for the reactivation of plant DNA synthesis, which is crucial for tumor progression in leaf cells. By contrast, See1 does not affect tumor formation in immature tassel floral tissues, where maize cell proliferation occurs independent of fungal infection. See1 interacts with a maize homolog of SGT1 (Suppressor of G2 allele of skp1), a factor acting in cell cycle progression in yeast (Saccharomyces cerevisiae) and an important component of plant and human innate immunity. See1 interferes with the MAPK-triggered phosphorylation of maize SGT1 at a monocot-specific phosphorylation site. We propose that See1 interferes with SGT1 activity, resulting in both modulation of immune responses and reactivation of DNA synthesis in leaf cells. This identifies See1 as a fungal effector that directly and specifically contributes to the formation of leaf tumors in maize.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Redkar, Amey UNSPECIFIED orcid.org/0000-0001-5171-8061 UNSPECIFIED Hoser, Rafal UNSPECIFIED UNSPECIFIED UNSPECIFIED Schilling, Lena UNSPECIFIED UNSPECIFIED UNSPECIFIED Zechmann, Bernd UNSPECIFIED orcid.org/0000-0002-7702-2588 UNSPECIFIED Krzymowska, Magdalena UNSPECIFIED orcid.org/0000-0001-9016-9165 UNSPECIFIED Walbot, Virginia UNSPECIFIED UNSPECIFIED UNSPECIFIED Doehlemann, Gunther UNSPECIFIED orcid.org/0000-0002-7353-8456 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-404448
DOI:	10.1105/tpc.114.131086
Journal or Publication Title:	Plant Cell
Volume:	27
Number:	4
Page Range:	S. 1332 - 1352
Date:	2015
Publisher:	AMER SOC PLANT BIOLOGISTS
Place of Publication:	ROCKVILLE
ISSN:	1532-298X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PLANT IMMUNE-RESPONSE; DISEASE RESISTANCE; PSEUDOMONAS-SYRINGAE; ESSENTIAL COMPONENT; GENE-EXPRESSION; TOBACCO PLANTS; HOST IMMUNITY; SGT1; ARABIDOPSIS; PATHOGEN Multiple languages Biochemistry & Molecular Biology; Plant Sciences; Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/40444