Siegert, Sabine, Roewer, Lutz ORCID: 0000-0001-9383-4941 and Nothnagel, Michael ORCID: 0000-0001-8305-7114 (2015). Shannon's equivocation for forensic Y-STR marker selection. Forensic Sci. Int.-Genet., 16. S. 216 - 226. CLARE: ELSEVIER IRELAND LTD. ISSN 1878-0326

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Abstract

Short tandem repeat (STR) markers are widely and continuously used in forensic applications. However, past research has demonstrated substantial allelic association between STR markers on both autosomes and the X chromosome, leading to partially redundant information that these markers can provide. Here, we quantify the allelic association between Y-chromosomal STR markers that are part of established forensic panels, separately for three different continental groups. We further propose a sequential marker selection procedure that is based on Shannon's equivocation and that accounts for allelic association between STR markers, leading to a maximal gain in independent information. In application to three real-world data sets, we demonstrate the procedure's superior performance when compared to single-locus diversity selection strategies, resulting in the optimal marker set for a given data set in the majority of marker subsets. Noting the inferior performance of the established Y-STR marker panels in a retrospective investigation, we suggest that future forensic marker selection should be guided, besides by other technical selection criteria, by an equivocation-based approach to obtain maximally discriminatory marker sets at minimal cost. (c) 2015 Elsevier Ireland Ltd. All rights reserved.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Siegert, SabineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roewer, LutzUNSPECIFIEDorcid.org/0000-0001-9383-4941UNSPECIFIED
Nothnagel, MichaelUNSPECIFIEDorcid.org/0000-0001-8305-7114UNSPECIFIED
URN: urn:nbn:de:hbz:38-404680
DOI: 10.1016/j.fsigen.2015.02.001
Journal or Publication Title: Forensic Sci. Int.-Genet.
Volume: 16
Page Range: S. 216 - 226
Date: 2015
Publisher: ELSEVIER IRELAND LTD
Place of Publication: CLARE
ISSN: 1878-0326
Language: English
Faculty: Faculty of Mathematics and Natural Sciences
Divisions: Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
LINKAGE DISEQUILIBRIUM; MICROSATELLITE MARKERSMultiple languages
Genetics & Heredity; Medicine, LegalMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/40468

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