Universität zu Köln

Hoffstaedter, F., Grefkes, C., Roski, C., Caspers, S., Zilles, K. and Eickhoff, S. B. (2015). Age-related decrease of functional connectivity additional to gray matter atrophy in a network for movement initiation. Brain Struct. Funct., 220 (2). S. 999 - 1013. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1863-2661

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Abstract

Healthy aging is accompanied by a decrease in cognitive and motor capacities. In a network associated with movement initiation, we investigated age-related changes of functional connectivity (FC) as well as regional atrophy in a sample of 232 healthy subjects (age range 18-85 years). To this end, voxel-based morphometry and whole-brain resting-state FC were analyzed for the supplementary motor area (SMA), anterior midcingulate cortex (aMCC) and bilateral striatum (Str). To assess the specificity of age-related effects, bilateral primary sensorimotor cortex (S1/M1) closely associated with motor execution was used as control seeds. All regions showed strong reduction of gray matter volume with age. Corrected for this regional atrophy, the FC analysis revealed an age x seed interaction for each of the bilateral Str nodes against S1/M1 with consistent age-related decrease in FC with bilateral caudate nucleus and anterior putamen. Specific age-dependent FC decline of SMA was found in bilateral central insula and the adjacent frontal operculum. aMCC showed exclusive age-related decoupling from the anterior cingulate motor area. The present study demonstrates network as well as node-specific age-dependent FC decline of the SMA and aMCC to highly integrative cortical areas involved in cognitive motor control. FC decrease in addition to gray matter atrophy within the Str may provide a substrate for the declining motor control in elderly. Finally, age-related FC changes in both the network for movement initiation as well as the network for motor execution are not explained by regional atrophy in the healthy aging brain.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hoffstaedter, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Grefkes, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Roski, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Caspers, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zilles, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Eickhoff, S. B. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-406247
DOI:	10.1007/s00429-013-0696-2
Journal or Publication Title:	Brain Struct. Funct.
Volume:	220
Number:	2
Page Range:	S. 999 - 1013
Date:	2015
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1863-2661
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SUPPLEMENTARY MOTOR AREAS; ANTERIOR CINGULATE CORTEX; RESTING-STATE; VOLUNTARY MOVEMENT; BASAL GANGLIA; HUMAN BRAIN; INDIVIDUAL-DIFFERENCES; REGIONAL HOMOGENEITY; FMRI; ARCHITECTURE Multiple languages Anatomy & Morphology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/40624