Universität zu Köln

Cornelius, Jan F., Stoffels, Gabriele ORCID: 0000-0001-7114-1941, Filss, Christian ORCID: 0000-0002-9927-6335, Galldiks, Norbert ORCID: 0000-0002-2485-1796, Slotty, Philipp, Kamp, Marcel ORCID: 0000-0002-1252-2944, el Khatib, Mustafa, Haenggi, Daniel, Sabel, Michael, Felsberg, Joerg, Steiger, Hans Jakob, Coenen, Heinz H., Shah, Nadim J. and Langen, Karl-Josef ORCID: 0000-0003-1101-5075 (2015). Uptake and tracer kinetics of O-(2-F-18-fluoroethyl)-L-tyrosine in meningiomas: preliminary results. Eur. J. Nucl. Med. Mol. Imaging, 42 (3). S. 459 - 468. NEW YORK: SPRINGER. ISSN 1619-7089

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Abstract

O-(2-[F-18]Fluoroethyl)-l-tyrosine (F-18-FET) is a well-established PET tracer for the imaging of cerebral gliomas, but little is known about F-18-FET uptake in meningiomas. The aim of this study was to explore F-18-FET kinetics and tumour-to-background contrast in meningiomas of various histologies. A group of 24 patients with suspected cerebral meningioma on MRI/CT had an additional dynamic F-18-FET PET scan prior to surgery. Time-activity curves (TAC) of F-18-FET uptake in the tumours and tumour-to-brain ratios (TBR) for early (3 - 14 min after injection) and late F-18-FET uptake (20 - 40 min after injection) were analysed and compared with histological subtypes and WHO grade. F-18-FET uptake in critical structures in the skull base was also evaluated in terms of tumour-to-tissue (T/Tis) ratio. TBR of F-18-FET uptake in meningiomas was significantly higher in the early phase than in the late phase (3.5 +/- 0.8 vs. 2.2 +/- 0.3; P < 0.001). The difference in TBR between low-grade meningiomas (WHO grade I, 18 patients) and high-grade meningiomas (WHO grade II or III, 6 patients) was significant in the late phase of F-18-FET uptake (2.1 +/- 0.2 vs. 2.5 +/- 0.2, P = 0.003) while there was no significant difference in the early phase. ROC analysis showed that TBR of F-18-FET uptake in the late phase had significant power to differentiate low-grade from high-grade meningiomas (AUC 0.87 +/- 0.18, sensitivity 83 %, specificity 83 %, optimal cut-off 2.3; P < 0.01). Evaluation of TAC yielded three different curve patterns of F-18-FET PET uptake. Combination of TBR (cut-off value 2.3) and TAC pattern slightly improved the differentiation of high-grade from low-grade meningiomas (accuracy 92 %; P = 0.001). Analysis of background radioactivity in the skull base indicated that F-18-FET uptake may be helpful in distinguishing meningioma tissue in the late phase. T/Tis ratios were > 1.2 in all patients for the periorbita, sphenoidal sinus, pituitary gland, tentorium, bone and brain, in more than 90 % of patients for the mucosa and dura, but in only 63 % of patients for the cavernous sinus. F-18-FET PET may provide additional information for noninvasive grading of meningiomas and possibly for the discrimination of tumour in critical areas of the skull base. A further evaluation of F-18-FET PET in meningiomas appears to be justified.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Cornelius, Jan F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Stoffels, Gabriele UNSPECIFIED orcid.org/0000-0001-7114-1941 UNSPECIFIED Filss, Christian UNSPECIFIED orcid.org/0000-0002-9927-6335 UNSPECIFIED Galldiks, Norbert UNSPECIFIED orcid.org/0000-0002-2485-1796 UNSPECIFIED Slotty, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Kamp, Marcel UNSPECIFIED orcid.org/0000-0002-1252-2944 UNSPECIFIED el Khatib, Mustafa UNSPECIFIED UNSPECIFIED UNSPECIFIED Haenggi, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Sabel, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Felsberg, Joerg UNSPECIFIED UNSPECIFIED UNSPECIFIED Steiger, Hans Jakob UNSPECIFIED UNSPECIFIED UNSPECIFIED Coenen, Heinz H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Shah, Nadim J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Langen, Karl-Josef UNSPECIFIED orcid.org/0000-0003-1101-5075 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-406512
DOI:	10.1007/s00259-014-2934-0
Journal or Publication Title:	Eur. J. Nucl. Med. Mol. Imaging
Volume:	42
Number:	3
Page Range:	S. 459 - 468
Date:	2015
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1619-7089
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language POSITRON-EMISSION-TOMOGRAPHY; INTRACRANIAL MENINGIOMA; ANAPLASTIC MENINGIOMAS; F-18-FDG PET; BASE; CLASSIFICATION; HYPEROSTOSIS; RECURRENCE; IMPROVES; REMOVAL Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/40651