Universität zu Köln

Goepel, Wolfgang, Kribs, Angela, Haertel, Christoph, Avenarius, Stefan, Teig, Norbert, Groneck, Peter, Olbertz, Dirk, Roll, Claudia, Vochem, Matthias, Weller, Ursula, von der Wense, Axel, Wieg, Christian, Wintgens, Juergen, Preuss, Michael ORCID: 0000-0001-5266-8465, Ziegler, Andreas ORCID: 0000-0002-8386-5397, Roth, Bernhard and Herting, Egbert (2015). Less invasive surfactant administration is associated with improved pulmonary outcomes in spontaneously breathing preterm infants. Acta Paediatr., 104 (3). S. 241 - 247. HOBOKEN: WILEY-BLACKWELL. ISSN 1651-2227

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Abstract

AimProviding less invasive surfactant administration (LISA) to spontaneously breathing preterm infants has been reported to reduce mechanical ventilation and bronchopulmonary dysplasia (BPD) in randomised controlled trials. This large cohort study compared these outcome measures between LISA-treated infants and controls. MethodsInfants receiving LISA, who were born before 32 gestational weeks and enrolled in the German Neonatal Network, were matched to control infants by gestational age, umbilical cord pH, Apgar-score at 5min, small for gestational age status, antenatal treatment with steroids, gender and highest supplemental oxygen during the first 12h of life. Outcome data were compared with chi-square and Mann-Whitney U-tests and adjusted for multiple comparisons. ResultsBetween 2009 and 2012, 1103 infants were treated with LISA at 37 centres. LISA infants had lower rates of mechanical ventilation (41% versus 62%, p<0.001), postnatal dexamethasone treatment (2.5% versus 7%, p<0.001), BPD (12% versus 18%, p=0.001) and BPD or death (14% versus 21%, p<0.001) than the controls. ConclusionSurfactant treatment of spontaneously breathing infants was associated with lower rates of mechanical ventilation and BPD. Additional large-scale randomised controlled trials are needed to assess the possible long-term benefits of LISA.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Goepel, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Kribs, Angela UNSPECIFIED UNSPECIFIED UNSPECIFIED Haertel, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Avenarius, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Teig, Norbert UNSPECIFIED UNSPECIFIED UNSPECIFIED Groneck, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Olbertz, Dirk UNSPECIFIED UNSPECIFIED UNSPECIFIED Roll, Claudia UNSPECIFIED UNSPECIFIED UNSPECIFIED Vochem, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Weller, Ursula UNSPECIFIED UNSPECIFIED UNSPECIFIED von der Wense, Axel UNSPECIFIED UNSPECIFIED UNSPECIFIED Wieg, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Wintgens, Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED Preuss, Michael UNSPECIFIED orcid.org/0000-0001-5266-8465 UNSPECIFIED Ziegler, Andreas UNSPECIFIED orcid.org/0000-0002-8386-5397 UNSPECIFIED Roth, Bernhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Herting, Egbert UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-406604
DOI:	10.1111/apa.12883
Journal or Publication Title:	Acta Paediatr.
Volume:	104
Number:	3
Page Range:	S. 241 - 247
Date:	2015
Publisher:	WILEY-BLACKWELL
Place of Publication:	HOBOKEN
ISSN:	1651-2227
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RESPIRATORY-DISTRESS; CONTROLLED-TRIAL; MORTALITY; THERAPY; VENTILATION; MORBIDITY; NEWBORNS; INJURY; NCPAP; BIRTH Multiple languages Pediatrics Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/40660