Universität zu Köln

Schmidt, S. J., Schultze-Lutter, F., Schimmelmann, B. G., Maric, N. P., Salokangas, R. K. R., Riecher-Roessler, A., van der Gaag, M., Meneghelli, A., Nordentoft, M., Marshall, M., Morrison, A., Raballo, A., Klosterkoetter, J. and Ruhrmann, S. (2015). EPA guidance on the early intervention in clinical high risk states of psychoses. Eur. Psychiat., 30 (3). S. 388 - 405. ISSY-LES-MOULINEAUX: ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER. ISSN 1778-3585

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Abstract

This guidance paper from the European Psychiatric Association (EPA) aims to provide evidence-based recommendations on early intervention in clinical high risk (CHR) states of psychosis, assessed according to the EPA guidance on early detection. The recommendations were derived from a meta-analysis of current empirical evidence on the efficacy of psychological and pharmacological interventions in CHR samples. Eligible studies had to investigate conversion rate and/or functioning as a treatment outcome in CHR patients defined by the ultra-high risk and/or basic symptom criteria. Besides analyses on treatment effects on conversion rate and functional outcome, age and type of intervention were examined as potential moderators. Based on data from 15 studies (n = 1394), early intervention generally produced significantly reduced conversion rates at 6-to 48-month follow-up compared to control conditions. However, early intervention failed to achieve significantly greater functional improvements because both early intervention and control conditions produced similar positive effects. With regard to the type of intervention, both psychological and pharmacological interventions produced significant effects on conversion rates, but not on functional outcome relative to the control conditions. Early intervention in youth samples was generally less effective than in predominantly adult samples. Seven evidence-based recommendations for early intervention in CHR samples could have been formulated, although more studies are needed to investigate the specificity of treatment effects and potential age effects in order to tailor interventions to the individual treatment needs and risk status. (C) 2015 Elsevier Masson SAS. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schmidt, S. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schultze-Lutter, F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schimmelmann, B. G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Maric, N. P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Salokangas, R. K. R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Riecher-Roessler, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED van der Gaag, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Meneghelli, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Nordentoft, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Marshall, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Morrison, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Raballo, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Klosterkoetter, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruhrmann, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-406819
DOI:	10.1016/j.eurpsy.2015.01.013
Journal or Publication Title:	Eur. Psychiat.
Volume:	30
Number:	3
Page Range:	S. 388 - 405
Date:	2015
Publisher:	ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
Place of Publication:	ISSY-LES-MOULINEAUX
ISSN:	1778-3585
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ULTRA-HIGH RISK; RANDOMIZED CONTROLLED-TRIAL; COGNITIVE-BEHAVIORAL THERAPY; QUALITY-OF-LIFE; YOUNG-PEOPLE; AT-RISK; FOLLOW-UP; 1ST-EPISODE PSYCHOSIS; INDICATED PREVENTION; GLYCINE TREATMENT Multiple languages Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/40681