Universität zu Köln

Woitalla, Dirk, Kassubek, Jan ORCID: 0000-0002-7106-9270, Timmermann, Lars, Lauterbach, Thomas, Berkels, Reinhard, Grieger, Frank and Mueller, Thomas (2015). Reduction of gastrointestinal symptoms in Parkinson's disease after a switch from oral therapy to rotigotine transdermal patch: A non-interventional prospective multicenter trial. Parkinsonism Relat. Disord., 21 (3). S. 199 - 205. OXFORD: ELSEVIER SCI LTD. ISSN 1873-5126

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Abstract

Introduction: Gastrointestinal (GI) symptoms are common among patients with Parkinson's disease (PD), due to both the disease itself and anti-PD drugs. We hypothesized that transdermal drug administration may result in fewer GI problems. This prospective observational study (ClinicalTrials.gov: NCT01159691) investigated effect of switching to rotigotine transdermal patch from oral anti-PD medications in patients with PD and existing GI symptoms. Methods: Patients were enrolled if their physician was planning to switch them to rotigotine because of GI symptoms experienced while receiving oral anti-PD medications. Effectiveness assessments included a visual analog scale (VAS) measuring intensity of GI symptoms from 0 (no disorder) to 100 mm (extremely severe disorder), a questionnaire on the frequency and intensity of six individual GI complaints (heartburn, bloating, nausea, vomiting, abdominal pain, diarrhea), each rated 0-12 for a sum score of 0-72, and patient satisfaction regarding GI symptoms over approximately 6 weeks after switching. Results: Of 75 patients who received rotigotine, 58 had follow-up data available for final analysis. Intensity of GI complaints improved numerically on both the VAS (47.5 +/- 24.4 mm [n = 65] at baseline, 19.7 +/- 23.3 mm [n = 58] after around 6 weeks) and the sum score of GI complaints (11.2 +/- 9.0 at baseline, 2.1 +/- 4.4 [n = 58] after around 6 weeks). Fifty of 58 patients were satisfied or very satisfied regarding GI symptoms over around 6 weeks following switch to the patch. Conclusion: This study suggests that a switch from oral anti-PD medications to rotigotine transdermal patch may improve existing GI symptoms among patients with PD. Additional controlled studies are needed to confirm this finding. (C) 2014 Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Woitalla, Dirk UNSPECIFIED UNSPECIFIED UNSPECIFIED Kassubek, Jan UNSPECIFIED orcid.org/0000-0002-7106-9270 UNSPECIFIED Timmermann, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED Lauterbach, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Berkels, Reinhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Grieger, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-407049
DOI:	10.1016/j.parkreldis.2014.11.024
Journal or Publication Title:	Parkinsonism Relat. Disord.
Volume:	21
Number:	3
Page Range:	S. 199 - 205
Date:	2015
Publisher:	ELSEVIER SCI LTD
Place of Publication:	OXFORD
ISSN:	1873-5126
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ENTERIC NERVOUS-SYSTEM; OVERNIGHT SWITCH; DOUBLE-BLIND; LEWY BODIES; RECEPTOR; CONSTIPATION; INCLUSIONS; ROPINIROLE; PATHOLOGY; MOTILITY Multiple languages Clinical Neurology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/40704