Universität zu Köln

Bergami, Matteo ORCID: 0000-0001-5525-5025, Masserdotti, Giacomo, Temprana, Silvio G., Motori, Elisa, Eriksson, Therese M., Goebel, Jana, Yang, Sung Min, Conzelmann, Karl-Klaus ORCID: 0000-0002-8614-3656, Schinder, Alejandro F., Goetz, Magdalena and Berninger, Benedikt ORCID: 0000-0003-2652-2782 (2015). A Critical Period for Experience-Dependent Remodeling of Adult-Born Neuron Connectivity. Neuron, 85 (4). S. 710 - 718. CAMBRIDGE: CELL PRESS. ISSN 1097-4199

Full text not available from this repository.

Abstract

Neurogenesis in the dentate gyrus (DG) of the adult hippocampus is a process regulated by experience. To understand whether experience also modifies the connectivity of new neurons, we systematically investigated changes in their innervation following environmental enrichment (EE). We found that EE exposure between 2-6 weeks following neuron birth, rather than merely increasing the number of new neurons, profoundly affected their pattern of monosynaptic inputs. Both local innervation by interneurons and to even greater degree long-distance innervation by cortical neurons were markedly enhanced. Furthermore, following EE, new neurons received inputs from CA3 and CA1 inhibitory neurons that were rarely observed under control conditions. While EE-induced changes in inhibitory innervation were largely transient, cortical innervation remained increased after returning animals to control conditions. Our findings demonstrate an unprecedented experience-dependent reorganization of connections impinging onto adult-born neurons, which is likely to have important impact on their contribution to hippocampal information processing.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bergami, Matteo UNSPECIFIED orcid.org/0000-0001-5525-5025 UNSPECIFIED Masserdotti, Giacomo UNSPECIFIED UNSPECIFIED UNSPECIFIED Temprana, Silvio G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Motori, Elisa UNSPECIFIED UNSPECIFIED UNSPECIFIED Eriksson, Therese M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Goebel, Jana UNSPECIFIED UNSPECIFIED UNSPECIFIED Yang, Sung Min UNSPECIFIED UNSPECIFIED UNSPECIFIED Conzelmann, Karl-Klaus UNSPECIFIED orcid.org/0000-0002-8614-3656 UNSPECIFIED Schinder, Alejandro F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Goetz, Magdalena UNSPECIFIED UNSPECIFIED UNSPECIFIED Berninger, Benedikt UNSPECIFIED orcid.org/0000-0003-2652-2782 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-407372
DOI:	10.1016/j.neuron.2015.01.001
Journal or Publication Title:	Neuron
Volume:	85
Number:	4
Page Range:	S. 710 - 718
Date:	2015
Publisher:	CELL PRESS
Place of Publication:	CAMBRIDGE
ISSN:	1097-4199
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ENHANCED SYNAPTIC PLASTICITY; GENERATED GRANULE CELLS; DENTATE GYRUS; HIPPOCAMPAL NEUROGENESIS; PATTERN SEPARATION; RABIES VIRUS; INTEGRATION; ACTIVATION; MATURATION; BEHAVIOR Multiple languages Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/40737